Glycogenic induction of thyroid hormone conversion and leptin system activation in the liver of postpartum dairy cows

Andrea Gyorffy, Mónika Keresztes, Vera Faigl, L. Frenyó, M. Kulcsár, Tibor Gaál, M. Mézes, A. Zsarnovszky, G. Huszenicza, T. Bartha

Research output: Contribution to journalArticle

Abstract

In the regulation of energy metabolism, the liver plays an important role in the reinforcement of energy production. In periparturient cows the energy homeostasis turns into a negative energy balance that may shift the physiological regulation of energy balance towards pathological processes. Propylene glycol (PG), as a complementary source of energy used in the nutrition of dairy cows, alters systemic thyroid hormone economy; however, the exact mechanism through which highly glycogenic feed supplements impact liver metabolism is little known. Previous studies showed that only leptin receptors are expressed in the liver of cows, and now we report that leptin mRNA is expressed in the liver of cows as well. The present results show that the mRNA of leptin and its receptors are differentially modulated by the increased energy content of the feed consumed. Simultaneous changes in hepatic type I deiodinase activity suggest that hepatic modulation of the leptin system by PG supplementation may be mediated by an increased local thyroxine-triiodothyronine conversion. Since PG supplementation with simultaneous T4-T3 turnover and increased hepatic leptin- and short-form leptin receptor mRNA were not associated with a significant change in hepatic total lipid levels, it is suggested that the leptin system, directly or indirectly modulated by thyroid hormones, may represent a local defence mechanism to prevent fatty liver formation.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalActa Veterinaria Hungarica
Volume57
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

thyroid hormones
Leptin
leptin
Thyroid Hormones
Postpartum Period
dairy cows
liver
Liver
Leptin Receptors
Propylene Glycol
propylene glycol
triiodothyronine
cows
energy balance
Messenger RNA
energy
physiological regulation
Iodide Peroxidase
feed supplements
L-thyroxine

Keywords

  • Cows
  • Fatty liver
  • Leptin
  • Propylene glycol
  • Thyroid hormones

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Glycogenic induction of thyroid hormone conversion and leptin system activation in the liver of postpartum dairy cows. / Gyorffy, Andrea; Keresztes, Mónika; Faigl, Vera; Frenyó, L.; Kulcsár, M.; Gaál, Tibor; Mézes, M.; Zsarnovszky, A.; Huszenicza, G.; Bartha, T.

In: Acta Veterinaria Hungarica, Vol. 57, No. 1, 2009, p. 139-146.

Research output: Contribution to journalArticle

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