Glutaurine enhances the depressed NK cell activity of tumor patients

I. Láng, L. Feuer, K. Nékám, A. Szigeti, P. Gergely, G. Petrányi

Research output: Contribution to journalArticle

Abstract

The effect of glutaurine, a newly discovered parathyroid substance, on human NK cell activity and on lymphocyte markers was studied. Both in vivo and in vitro treatment with glutaurine markedly enhanced the depressed natural lymphocytotoxicity of tumor patients without influencing their lymphocyte subpopulations. On the other hand it had no effect on the NK cell activity of healthy lymphocytes and of tumor patients' lymphocytes with originally 'normal' NK activity. The NK-enhancing effect of glutaurine could not be explained by augmentation of the number of potential effector cells. It is suggested that glutaurine increases the originally low spontaneous killer activity of tumor patients' lymphocytes through an indirect regulatory mechanism.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
JournalImmunological Communications
Volume12
Issue number5
Publication statusPublished - 1983

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Natural Killer Cells
Lymphocytes
Neoplasms
Lymphocyte Subsets
glutaurine
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Láng, I., Feuer, L., Nékám, K., Szigeti, A., Gergely, P., & Petrányi, G. (1983). Glutaurine enhances the depressed NK cell activity of tumor patients. Immunological Communications, 12(5), 519-527.

Glutaurine enhances the depressed NK cell activity of tumor patients. / Láng, I.; Feuer, L.; Nékám, K.; Szigeti, A.; Gergely, P.; Petrányi, G.

In: Immunological Communications, Vol. 12, No. 5, 1983, p. 519-527.

Research output: Contribution to journalArticle

Láng, I, Feuer, L, Nékám, K, Szigeti, A, Gergely, P & Petrányi, G 1983, 'Glutaurine enhances the depressed NK cell activity of tumor patients', Immunological Communications, vol. 12, no. 5, pp. 519-527.
Láng, I. ; Feuer, L. ; Nékám, K. ; Szigeti, A. ; Gergely, P. ; Petrányi, G. / Glutaurine enhances the depressed NK cell activity of tumor patients. In: Immunological Communications. 1983 ; Vol. 12, No. 5. pp. 519-527.
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