Glutathione as an antioxidant and regulatory molecule in plants under abiotic stress conditions

G. Szalai, Tibor Kellos, G. Galiba, G. Kocsy

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

The glutathione (GSH)/glutathione disulfide (GSSG) redox couple is involved in several physiologic processes in plants under both optimal and stress conditions. It participates in the maintenance of redox homeostasis in the cells. The redox state of the GSH/GSSG couple is defined by its reducing capacity and the half-cell reduction potential, and differs in the various organs, tissues, cells, and compartments, changing during the growth and development of the plants. When characterizing this redox couple, the synthesis, degradation, oxidation, and transport of GSH and its conjugation with the sulfhydryl groups of other compounds should be considered. Under optimal growth conditions, the high GSH/GSSG ratio results in a reducing environment in the cells which maintains the appropriate structure and activity of protein molecules because of the inhibition of the formation of intermolecular disulfide bridges. In response to abiotic stresses, the GSH/GSSG ratio decreases due to the oxidation of GSH during the detoxification of reactive oxygen species (ROS) and changes in its metabolism. The lower GSH/GSSG ratio activates various defense mechanisms through a redox signalling pathway, which includes several oxidants, antioxidants, and stress hormones. In addition, GSH may control gene expression and the activity of proteins through glutathionylation and thiol-disulfide conversion. This review discusses the size and redox state of the GSH pool, including their regulation, their role in redox signalling and defense processes, and the changes caused by abiotic stress.

Original languageEnglish
Pages (from-to)66-80
Number of pages15
JournalJournal of Plant Growth Regulation
Volume28
Issue number1
DOIs
Publication statusPublished - Mar 2009

Fingerprint

abiotic stress
glutathione
sulfides
antioxidants
cells
oxidation
sulfhydryl groups
thiols
defense mechanisms
oxidants
reactive oxygen species
homeostasis
growth and development
proteins
hormones
gene expression
metabolism
synthesis
degradation

Keywords

  • Abiotic stress
  • Glutathione
  • Glutathionylation
  • Reactive oxygen species
  • Redox signalling

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science

Cite this

Glutathione as an antioxidant and regulatory molecule in plants under abiotic stress conditions. / Szalai, G.; Kellos, Tibor; Galiba, G.; Kocsy, G.

In: Journal of Plant Growth Regulation, Vol. 28, No. 1, 03.2009, p. 66-80.

Research output: Contribution to journalArticle

@article{a4cb6c36eb54408bb1cc394a0129222b,
title = "Glutathione as an antioxidant and regulatory molecule in plants under abiotic stress conditions",
abstract = "The glutathione (GSH)/glutathione disulfide (GSSG) redox couple is involved in several physiologic processes in plants under both optimal and stress conditions. It participates in the maintenance of redox homeostasis in the cells. The redox state of the GSH/GSSG couple is defined by its reducing capacity and the half-cell reduction potential, and differs in the various organs, tissues, cells, and compartments, changing during the growth and development of the plants. When characterizing this redox couple, the synthesis, degradation, oxidation, and transport of GSH and its conjugation with the sulfhydryl groups of other compounds should be considered. Under optimal growth conditions, the high GSH/GSSG ratio results in a reducing environment in the cells which maintains the appropriate structure and activity of protein molecules because of the inhibition of the formation of intermolecular disulfide bridges. In response to abiotic stresses, the GSH/GSSG ratio decreases due to the oxidation of GSH during the detoxification of reactive oxygen species (ROS) and changes in its metabolism. The lower GSH/GSSG ratio activates various defense mechanisms through a redox signalling pathway, which includes several oxidants, antioxidants, and stress hormones. In addition, GSH may control gene expression and the activity of proteins through glutathionylation and thiol-disulfide conversion. This review discusses the size and redox state of the GSH pool, including their regulation, their role in redox signalling and defense processes, and the changes caused by abiotic stress.",
keywords = "Abiotic stress, Glutathione, Glutathionylation, Reactive oxygen species, Redox signalling",
author = "G. Szalai and Tibor Kellos and G. Galiba and G. Kocsy",
year = "2009",
month = "3",
doi = "10.1007/s00344-008-9075-2",
language = "English",
volume = "28",
pages = "66--80",
journal = "Journal of Plant Growth Regulation",
issn = "0721-7595",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Glutathione as an antioxidant and regulatory molecule in plants under abiotic stress conditions

AU - Szalai, G.

AU - Kellos, Tibor

AU - Galiba, G.

AU - Kocsy, G.

PY - 2009/3

Y1 - 2009/3

N2 - The glutathione (GSH)/glutathione disulfide (GSSG) redox couple is involved in several physiologic processes in plants under both optimal and stress conditions. It participates in the maintenance of redox homeostasis in the cells. The redox state of the GSH/GSSG couple is defined by its reducing capacity and the half-cell reduction potential, and differs in the various organs, tissues, cells, and compartments, changing during the growth and development of the plants. When characterizing this redox couple, the synthesis, degradation, oxidation, and transport of GSH and its conjugation with the sulfhydryl groups of other compounds should be considered. Under optimal growth conditions, the high GSH/GSSG ratio results in a reducing environment in the cells which maintains the appropriate structure and activity of protein molecules because of the inhibition of the formation of intermolecular disulfide bridges. In response to abiotic stresses, the GSH/GSSG ratio decreases due to the oxidation of GSH during the detoxification of reactive oxygen species (ROS) and changes in its metabolism. The lower GSH/GSSG ratio activates various defense mechanisms through a redox signalling pathway, which includes several oxidants, antioxidants, and stress hormones. In addition, GSH may control gene expression and the activity of proteins through glutathionylation and thiol-disulfide conversion. This review discusses the size and redox state of the GSH pool, including their regulation, their role in redox signalling and defense processes, and the changes caused by abiotic stress.

AB - The glutathione (GSH)/glutathione disulfide (GSSG) redox couple is involved in several physiologic processes in plants under both optimal and stress conditions. It participates in the maintenance of redox homeostasis in the cells. The redox state of the GSH/GSSG couple is defined by its reducing capacity and the half-cell reduction potential, and differs in the various organs, tissues, cells, and compartments, changing during the growth and development of the plants. When characterizing this redox couple, the synthesis, degradation, oxidation, and transport of GSH and its conjugation with the sulfhydryl groups of other compounds should be considered. Under optimal growth conditions, the high GSH/GSSG ratio results in a reducing environment in the cells which maintains the appropriate structure and activity of protein molecules because of the inhibition of the formation of intermolecular disulfide bridges. In response to abiotic stresses, the GSH/GSSG ratio decreases due to the oxidation of GSH during the detoxification of reactive oxygen species (ROS) and changes in its metabolism. The lower GSH/GSSG ratio activates various defense mechanisms through a redox signalling pathway, which includes several oxidants, antioxidants, and stress hormones. In addition, GSH may control gene expression and the activity of proteins through glutathionylation and thiol-disulfide conversion. This review discusses the size and redox state of the GSH pool, including their regulation, their role in redox signalling and defense processes, and the changes caused by abiotic stress.

KW - Abiotic stress

KW - Glutathione

KW - Glutathionylation

KW - Reactive oxygen species

KW - Redox signalling

UR - http://www.scopus.com/inward/record.url?scp=67349263910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349263910&partnerID=8YFLogxK

U2 - 10.1007/s00344-008-9075-2

DO - 10.1007/s00344-008-9075-2

M3 - Article

VL - 28

SP - 66

EP - 80

JO - Journal of Plant Growth Regulation

JF - Journal of Plant Growth Regulation

SN - 0721-7595

IS - 1

ER -