Glutamatergic phenotype of hypothalamic neurosecretory systems

a novel aspect of central neuroendocrine regulation.

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1 Citation (Scopus)

Abstract

While three decades ago, the co-existence of classical neurotransmitters and peptide neuromodulators in a single neuronal cell was considered to be rather exceptional, the phenomenon that neurons have a complex transmitter phenotype now appears to be the general rule. Parvicellular and magnocellular neurosecretory systems consist of neuronal cells which are specialized in secreting peptide neurohormones into the blood-stream to regulate hypophyseal functions. This mini-review, dedicated to the memory of Mariann Fodor, summarizes the current knowledge about the classical neurotransmitter content of different hypothalamic neurosecretory systems, with a special focus on the occurrence and putative functions of glutamate in parvicellular and magnocellular neurosecretory cells.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalIdeggyógyászati szemle
Volume60
Issue number3-4
Publication statusPublished - Mar 30 2007

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Neurosecretory Systems
Neurotransmitter Agents
Phenotype
Peptides
Glutamic Acid
Neurons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "While three decades ago, the co-existence of classical neurotransmitters and peptide neuromodulators in a single neuronal cell was considered to be rather exceptional, the phenomenon that neurons have a complex transmitter phenotype now appears to be the general rule. Parvicellular and magnocellular neurosecretory systems consist of neuronal cells which are specialized in secreting peptide neurohormones into the blood-stream to regulate hypophyseal functions. This mini-review, dedicated to the memory of Mariann Fodor, summarizes the current knowledge about the classical neurotransmitter content of different hypothalamic neurosecretory systems, with a special focus on the occurrence and putative functions of glutamate in parvicellular and magnocellular neurosecretory cells.",
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