In premature infants kept at and below the neutral temperature blood lactate, plasma FFA, α-amino N2 and amino acid ratio in response to an intravenous glucose load has been examined within the first day of extrauterine life. On exposure to cold statistically insignificant changes in the mean glucose, lactate, FFA, α-amino N2 level and amino acid ratio was observed. The individual responses, however, were variable. The effect of an intravenous glucose load (0.5 g/kg) on blood lactate largely depends on environmental temperature. At 33–35°C, only a transient, at 26–28°C, however, a marked and sustained rise in blood concentration occurred. At thermal neutrality both the mean absolute and percentage changes in FFA in response to glucose showed an early transient rise with a subsequent fall below the fasting values. In the cool environment the plasma FFA appeared rather resistant as far as the mean absolute concentration, or percentage changes are concerned. According to the individual responses intravenous injection of glucose, in some instances, caused a marked increase in the plasma FFA concentration. α -Amino N2 level showed a gradual but statistically not significant fall in response to intravenous glucose under both environmental conditions. Both in the ‘warm’ and ‘cool’ infants, the falling tendency of the extinction values indicating the plasma concentration of the two groups of amino acids included in Whitehead’s amino acid quotient was quite obvious. The changes were proportional and thus the ratio of the nonessential and essential group of amino acids did not change appreciably during the glucose tolerance test.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology