Glucose transport and transporters in the endomembranes

Beáta Lizák, András Szarka, Yejin Kim, Kyu Sung Choi, Csilla E. Németh, Paola Marcolongo, Angelo Benedetti, Gábor Bánhegyi, Éva Margittai

Research output: Contribution to journalReview article

Abstract

Glucose is a basic nutrient in most of the creatures; its transport through biological membranes is an absolute requirement of life. This role is fulfilled by glucose transporters, mediating the transport of glucose by facilitated diffusion or by secondary active transport. GLUT (glucose transporter) or SLC2A (Solute carrier 2A) families represent the main glucose transporters in mammalian cells, originally described as plasma membrane transporters. Glucose transport through intracellular membranes has not been elucidated yet; however, glucose is formed in the lumen of various organelles. The glucose-6-phosphatase system catalyzing the last common step of gluconeogenesis and glycogenolysis generates glucose within the lumen of the endoplasmic reticulum. Posttranslational processing of the oligosaccharide moiety of glycoproteins also results in intraluminal glucose formation in the endoplasmic reticulum (ER) and Golgi. Autophagic degradation of polysaccharides, glycoproteins, and glycolipids leads to glucose accumulation in lysosomes. Despite the obvious necessity, the mechanism of glucose transport and the molecular nature of mediating proteins in the endomembranes have been hardly elucidated for the last few years. However, recent studies revealed the intracellular localization and functional features of some glucose transporters; the aim of the present paper was to summarize the collected knowledge.

Original languageEnglish
Article number5898
JournalInternational journal of molecular sciences
Volume20
Issue number23
DOIs
Publication statusPublished - Dec 1 2019

Fingerprint

transporter
Facilitative Glucose Transport Proteins
glucose
Glucose
Endoplasmic Reticulum
Glycoproteins
endoplasmic reticulum
Biological Transport
lumens
Facilitated Diffusion
Biological membranes
Glycogenolysis
Glucose-6-Phosphatase
membranes
Intracellular Membranes
Membrane Transport Proteins
Gluconeogenesis
Active Biological Transport
Glycolipids
Cell membranes

Keywords

  • Endomembrane
  • Glucose
  • GLUT
  • SGLT
  • Transporter

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Lizák, B., Szarka, A., Kim, Y., Choi, K. S., Németh, C. E., Marcolongo, P., ... Margittai, É. (2019). Glucose transport and transporters in the endomembranes. International journal of molecular sciences, 20(23), [5898]. https://doi.org/10.3390/ijms20235898

Glucose transport and transporters in the endomembranes. / Lizák, Beáta; Szarka, András; Kim, Yejin; Choi, Kyu Sung; Németh, Csilla E.; Marcolongo, Paola; Benedetti, Angelo; Bánhegyi, Gábor; Margittai, Éva.

In: International journal of molecular sciences, Vol. 20, No. 23, 5898, 01.12.2019.

Research output: Contribution to journalReview article

Lizák, B, Szarka, A, Kim, Y, Choi, KS, Németh, CE, Marcolongo, P, Benedetti, A, Bánhegyi, G & Margittai, É 2019, 'Glucose transport and transporters in the endomembranes', International journal of molecular sciences, vol. 20, no. 23, 5898. https://doi.org/10.3390/ijms20235898
Lizák B, Szarka A, Kim Y, Choi KS, Németh CE, Marcolongo P et al. Glucose transport and transporters in the endomembranes. International journal of molecular sciences. 2019 Dec 1;20(23). 5898. https://doi.org/10.3390/ijms20235898
Lizák, Beáta ; Szarka, András ; Kim, Yejin ; Choi, Kyu Sung ; Németh, Csilla E. ; Marcolongo, Paola ; Benedetti, Angelo ; Bánhegyi, Gábor ; Margittai, Éva. / Glucose transport and transporters in the endomembranes. In: International journal of molecular sciences. 2019 ; Vol. 20, No. 23.
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