Glucose-sensitive neurons of the globus pallidus

I. Neurochemical characteristics

L. Lénárd, Zoltán Karádi, Béla Faludi, A. Czurkó, Csaba Niedetzky, Imre Vida, Hitoo Nishino

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The lateral hypothalamic area (LHA) and globes pallidtaz (GP) are basically involved in the regulation of feeding and metabolic processes. In the LHA, glucose-sensitive (GS) neurons were described: their activity was found to be specifically suppressed by electrophoretic application of glucose, and these neurons appeared to be also influenced by various feeding-associated neurochemical signals. The main goal of the present experiments was to examine whether similar GS neurons exist in the GP. In addition, neurochemical attributes of the cells were also tested. In anesthetized rats and anesthetized or awake monkeys, single-neuron activity of the GP was recorded by means of carbon fiber multibarreled microelectrodes and the effects of glucose, glutamate (Gt), GABA, dopamine (DA), noradrenaline (NA) and acetylcholine (Ach) were studied. In both the rat and monkey GP, approximately 12% of the neurons examined responded, with inhibition, to glucose. GP neurons, in a high proportion, were also inhibited by GABA and NA. After application of Gt, DA, or Ach, activity increase or decrease occurred. GS neurons exhibited remarkable sensitivity to these neurochemicals previously identified as neurotransmitters of the complex pallidal, extrapyramidel-limbic neuron loops. The results, along with previous data, indicate that GS cells of the GP, while possessing complex neurochemical characteristics, may belong to a hierarchically organized central glucose-monitoring system essential in the regulation of feeding.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalBrain Research Bulletin
Volume37
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Globus Pallidus
Neurons
Glucose
Lateral Hypothalamic Area
gamma-Aminobutyric Acid
Acetylcholine
Haplorhini
Glutamic Acid
Dopamine
Norepinephrine
Microelectrodes
Neurotransmitter Agents

Keywords

  • Acetylcholine
  • Dopamine
  • Feeding
  • GABA
  • Glucose-monitoring system
  • Glutamate
  • Noradrenaline
  • Pallidum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Glucose-sensitive neurons of the globus pallidus : I. Neurochemical characteristics. / Lénárd, L.; Karádi, Zoltán; Faludi, Béla; Czurkó, A.; Niedetzky, Csaba; Vida, Imre; Nishino, Hitoo.

In: Brain Research Bulletin, Vol. 37, No. 2, 1995, p. 149-155.

Research output: Contribution to journalArticle

Lénárd, L. ; Karádi, Zoltán ; Faludi, Béla ; Czurkó, A. ; Niedetzky, Csaba ; Vida, Imre ; Nishino, Hitoo. / Glucose-sensitive neurons of the globus pallidus : I. Neurochemical characteristics. In: Brain Research Bulletin. 1995 ; Vol. 37, No. 2. pp. 149-155.
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