Glucose-sensitive neurons in the pallidum: Complex functional properties

L. Lénárd, Z. Karádi, B. Faludi, A. Czurkó

Research output: Contribution to journalArticle

Abstract

To provide feeding-related neurochemical and behavioral characterization of globus pallidus (GP) neurons, extracellular single neuron activity was recorded in the GP of alert rhesus monkeys by means of carbon-fibre multibarreled glass microelectrodes during: (1) microelectrophoretic administration of chemicals (glucose, catecholamines, Ach, GABA and excitatory amino acids) and (2) performance of a conditioned alimentary task. A high proportion, 17%, of all pallidal cells tested proved to be glucose-sensitive (GS), i.e. were suppressed in activity by microelectrophoretically applied glucose. Predominantly these GS neurons were those that displayed differential responses while the animal was presented with food vs. nonfood objects. GS cells, and less characteristically the glucose-insensitive neurons, exhibited complex firing rate patterns during the discriminative conditioned feeding task. These above subsets of pallidal neurons showed differential neurotransmitter sensitivities in the microiontophoretic studies. The present results, along with previous data, indicate that chemosensitive cells of the GP are under multiple neurotransmitter modulation and belong to the central glucose monitoring neural network integrating various feeding-associated sensory, motor, perceptual and motivational signals.

Original languageEnglish
Pages (from-to)87
Number of pages1
JournalAppetite
Volume24
Issue number1
Publication statusPublished - 1995

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Globus Pallidus
Neurons
Glucose
Neurotransmitter Agents
Excitatory Amino Acids
Microelectrodes
Macaca mulatta
gamma-Aminobutyric Acid
Catecholamines
Glass
Food

ASJC Scopus subject areas

  • Behavioral Neuroscience

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Glucose-sensitive neurons in the pallidum : Complex functional properties. / Lénárd, L.; Karádi, Z.; Faludi, B.; Czurkó, A.

In: Appetite, Vol. 24, No. 1, 1995, p. 87.

Research output: Contribution to journalArticle

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