Glucose metabolism in hypothalamic obese rats

M. Góth, C. Nyakas, E. Endroczi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Observations were performed on obese rats produced by bilateral electrolytic lesions of the ventromedial hypothalamic area. Ip administration of 10 μg/100 g adrenaline resulted in a significantly smaller rise of the plasma glucose concentration in obese rats than in sham operated controls. The administration of 0.15 U/100 g insulin led to the hypoglycemia of the same magnitude both in obese and sham operated rats. In contrast to these findings, the oral glucose loading produced a greater increase of the plasma glucose level of the obese animals than of the controls. Studying the pituitary adrenal function of the obese rats led to the assumption that the disturbance of the glucose metabolism cannot be attributed to a change in the pituitary adrenocortical axis and the discussion of the data raised different other alternatives to interpret the present findings.

Original languageEnglish
Title of host publicationEndokrinologie
Pages265-270
Number of pages6
Volume61
Edition2
Publication statusPublished - 1973

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Glucose
Hypoglycemia
Epinephrine
Insulin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Góth, M., Nyakas, C., & Endroczi, E. (1973). Glucose metabolism in hypothalamic obese rats. In Endokrinologie (2 ed., Vol. 61, pp. 265-270)

Glucose metabolism in hypothalamic obese rats. / Góth, M.; Nyakas, C.; Endroczi, E.

Endokrinologie. Vol. 61 2. ed. 1973. p. 265-270.

Research output: Chapter in Book/Report/Conference proceedingChapter

Góth, M, Nyakas, C & Endroczi, E 1973, Glucose metabolism in hypothalamic obese rats. in Endokrinologie. 2 edn, vol. 61, pp. 265-270.
Góth M, Nyakas C, Endroczi E. Glucose metabolism in hypothalamic obese rats. In Endokrinologie. 2 ed. Vol. 61. 1973. p. 265-270
Góth, M. ; Nyakas, C. ; Endroczi, E. / Glucose metabolism in hypothalamic obese rats. Endokrinologie. Vol. 61 2. ed. 1973. pp. 265-270
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