Glucocorticoids alter recovery processes in the rat retina

István Ábrahám, János Pálhalmi, Nóra Szilágyi, Gábor Juhász

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of glucocorticoids on the electroretinogram (ERG) b-wave was studied in freely moving rats. b-Waves were evoked by flashes delivered by a light emitting diode implanted under the skin above the left eye. I.v. corticosterone and dexamethasone injection induced a transient increase in b- wave amplitude at 90 min. Retinal oscillatory potentials (OPs) were similarly enhanced. Pretreatment with a glucocorticoid receptor antagonist (RU 38486) abolished both increases. These results suggest that enhancements in retinal potentials may be the result of a glucocorticoid-induced facilitation of the processes under way in normal Muller cells following retinal excitation.

Original languageEnglish
Pages (from-to)1465-1468
Number of pages4
JournalNeuroreport
Volume9
Issue number7
DOIs
Publication statusPublished - May 11 1998

Keywords

  • B-Wave
  • Corticosterone
  • Dexamethasone
  • Muller cells
  • Oscillatory potentials

ASJC Scopus subject areas

  • Neuroscience(all)

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