Glucocorticoid receptor expression and antiproliferative effect of dexamethasone on human melanoma cells

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Abstract

Glucocorticoids, such as dexamethasone are widely used in cancer therapy and have cell type-specific pro- or antiapoptotic effects. We examined whether melanoma cells are sensitive to dexamethasone treatment. We have demonstrated for the first time that in human melanoma cell lines as well as in benign and malignant melanocytic tumors glucocorticoid receptor (GCR) is present both at mRNA and protein level. Dexamethasone applied at high doses inhibited the in vitro growth of WM983A human melanoma cells. The inhibitory effect was due to apoptosis induction. In the case of this relatively sensitive cell line dexamethasone enhanced the effect of the chemotherapeutic drug DTIC.

Original languageEnglish
Pages (from-to)729-734
Number of pages6
JournalPathology and Oncology Research
Volume17
Issue number3
DOIs
Publication statusPublished - Sep 1 2011

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Keywords

  • Apoptosis
  • Chemotherapy
  • Dexamethasone
  • Glucocorticoid receptor
  • Melanoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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