Glomerulosa cell - A unique sensor of extracellular K+ concentration

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The adrenal glomerulosa cells is the cell type most sensitive to extracellular K+ in the mammalian organism. Its sensitivity to physiological increases in K+ concentration ([K+]) is due to the expression of the two-pore domain K+ channels TASK that gives rise to K+ conductance in the range of resting membrane potential (≅ -80 mV) and to mechanisms that reduce the activation threshold of T-type voltage-activated Ca2+ channels. Potassium-induced cytoplasmic Ca2+ signal activates adenylyl cyclase; induces and activates StAR, the protein that carries cholesterol to the inner mitochondrial membramne and also enhances the expression of aldosterone synthase. The cytoplasmic Ca 2+ signal is transferred into the mitochondrial matrix and enhances the reduction of mitochondrial pyridine nucleotides.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalMolecular and Cellular Endocrinology
Volume217
Issue number1-2
DOIs
Publication statusPublished - Mar 31 2004

Fingerprint

Cytochrome P-450 CYP11B2
Adenylyl Cyclases
Potassium
Nucleotides
Chemical activation
Cholesterol
Zona Glomerulosa
Membranes
Sensors
Electric potential
Membrane Potentials
Proteins
pyridine

Keywords

  • Aldosterone
  • Cell swelling
  • Glomerulosa cells
  • K conductance
  • Mitochondrial calcium
  • NAD(P)H
  • Potassium
  • Pyridine nucleotides
  • T-type Ca channel
  • TASK channel

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Glomerulosa cell - A unique sensor of extracellular K+ concentration. / Spät, A.

In: Molecular and Cellular Endocrinology, Vol. 217, No. 1-2, 31.03.2004, p. 23-26.

Research output: Contribution to journalArticle

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