Glomerular prostanoid production is modified by plasma samples of hypertensive and diabetic patients.

B. Székács, Z. Vajó, I. Juhász, L. Vaslaki, V. Nagy

Research output: Contribution to journalArticle

Abstract

The autocrin-paracrin prostanoid system plays a major role in the enhancement or inhibition of renal tissue damage. Our hypothesis was that there might be circulating factors in the plasma with a capability to modify renal (glomerular) prostanoid synthesis. We measured the synthesis of prostacyclin 1-2 (PGI2) and thromboxan A-2 (TxA2) of isolated glomeruli, incubated in plasma samples obtained from hypertensive and diabetic (NIDDM) patients. It was found that these plasma samples decreased the renal PGI2/TxA2 ratio, mostly by decreasing glomerular PGI2 synthesis and, to a lesser extent, increasing the synthesis of TxA2. Our results demonstrate that circulating factors in hypertension and diabetes might play a role in renal damage seen in these conditions.

Original languageEnglish
Pages (from-to)17-28
Number of pages12
JournalActa Physiologica Hungarica
Volume85
Issue number1
Publication statusPublished - 1997

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Epoprostenol
Prostaglandins
varespladib methyl
Kidney
Type 2 Diabetes Mellitus
Hypertension

ASJC Scopus subject areas

  • Physiology

Cite this

Glomerular prostanoid production is modified by plasma samples of hypertensive and diabetic patients. / Székács, B.; Vajó, Z.; Juhász, I.; Vaslaki, L.; Nagy, V.

In: Acta Physiologica Hungarica, Vol. 85, No. 1, 1997, p. 17-28.

Research output: Contribution to journalArticle

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