Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts

Takami Yagyu, Jiri Wackermann, Masahiro Shigeta, Vesna Jelic, Toshihiko Kinoshita, Kieko Kochi, Per Julin, Ove Almkvist, Lars Olof Wahlund, I. Kondákor, Dietrich Lehmann

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Multichannel EEG as sequence of momentary brain field maps constitutes a trajectory through K-dimensional state space (K = number of channels); the complexity of this trajectory is assessed by the nonlinear measure of global correlation dimension (Global Dimensional Complexity, GDC) with the number of electrodes as embedding dimension, We analyzed eyes-closed EEG of three age-matched subject groups: mild Alzheimer's disease (AD; n = 21), mild cognitive impairment (29) and subjective memory complaint (29). Kruskal-Wallis statistics showed an overall effect between groups. AD patients differed significantly (GDC = 4.56) from mild cognitive impairments (GDC = 4.98) and from subjective memory complaints (GDC = 4.93). GDC also had significant positive correlations with mental condition and performance (MMSE and WAIS-R scores). Thus, the dynamics of brain state development over time in mild AD differs from that in mild cognitive impairment and in subjective memory complaint cases.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume8
Issue number6
Publication statusPublished - Nov 1997

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Electroencephalography
Alzheimer Disease
Brain
Electrodes
Research Design
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Dementia
  • Global correlation dimension
  • Global dimensional complexity
  • Intellectual impairment
  • Multichannel EEG

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Yagyu, T., Wackermann, J., Shigeta, M., Jelic, V., Kinoshita, T., Kochi, K., ... Lehmann, D. (1997). Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts. Dementia and Geriatric Cognitive Disorders, 8(6), 343-347.

Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts. / Yagyu, Takami; Wackermann, Jiri; Shigeta, Masahiro; Jelic, Vesna; Kinoshita, Toshihiko; Kochi, Kieko; Julin, Per; Almkvist, Ove; Wahlund, Lars Olof; Kondákor, I.; Lehmann, Dietrich.

In: Dementia and Geriatric Cognitive Disorders, Vol. 8, No. 6, 11.1997, p. 343-347.

Research output: Contribution to journalArticle

Yagyu, T, Wackermann, J, Shigeta, M, Jelic, V, Kinoshita, T, Kochi, K, Julin, P, Almkvist, O, Wahlund, LO, Kondákor, I & Lehmann, D 1997, 'Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts', Dementia and Geriatric Cognitive Disorders, vol. 8, no. 6, pp. 343-347.
Yagyu T, Wackermann J, Shigeta M, Jelic V, Kinoshita T, Kochi K et al. Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts. Dementia and Geriatric Cognitive Disorders. 1997 Nov;8(6):343-347.
Yagyu, Takami ; Wackermann, Jiri ; Shigeta, Masahiro ; Jelic, Vesna ; Kinoshita, Toshihiko ; Kochi, Kieko ; Julin, Per ; Almkvist, Ove ; Wahlund, Lars Olof ; Kondákor, I. ; Lehmann, Dietrich. / Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts. In: Dementia and Geriatric Cognitive Disorders. 1997 ; Vol. 8, No. 6. pp. 343-347.
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