Global dimensional complexity of multichannel EEG in mild alzheimer’s disease and age-matched cohorts

Takami Yagyu, Jiri Wackermann, Masahiro Shigeta, Vesna Jelic, Toshihiko Kinoshita, Kieko Kochi, Per Julin, Ove Almkvist, Lars Olof Wahlund, Istvan Kondakor, Dietrich Lehmann

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Multichannel EEG as sequence of momentary brain field maps constitutes a trajectory through K-dimensional state space (K = number of channels); the complexity of this trajectory is assessed by the nonlinear measure of global correlation dimension (Global Dimensional Complexity, GDC) with the number of electrodes as embedding dimension. We analyzed eyes-closed EEG of three age-matched subject groups: mild Alzheimer’s disease (AD; n = 21), mild cognitive impairment (29) and subjective memory complaint (29). Kruskal-Wallis statistics showed an overall effect between groups. AD patients differed significantly (GDC = 4.56) from mild cognitive impairments (GDC = 4.98) and from subjective memory complaints (GDC = 4.93). GDC also had significant positive correlations with mental condition and performance (MMSE and WAIS-R scores). Thus, the dynamics of brain state development over time in mild AD differs from that in mild cognitive impairment and in subjective memory complaint cases.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume8
Issue number6
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • Alzheimer’s disease
  • Dementia
  • Global Dimensional Complexity
  • Global correlation dimension
  • Intellectual impairment
  • Multichannel EEG

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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    Yagyu, T., Wackermann, J., Shigeta, M., Jelic, V., Kinoshita, T., Kochi, K., Julin, P., Almkvist, O., Wahlund, L. O., Kondakor, I., & Lehmann, D. (1997). Global dimensional complexity of multichannel EEG in mild alzheimer’s disease and age-matched cohorts. Dementia and Geriatric Cognitive Disorders, 8(6), 343-347. https://doi.org/10.1159/000106653