Glibenclamide sensitivity of neural relaxation of the rabbit sphincter of Oddi

Z. Szilvássy, J. Lonovics, Ildiko Jakab, Istvan Nagy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this article we studied whether the nitrergic relaxation of the rabbit sphincter was sensitive to glibenclamide. Field stimulation relaxed the sphincter of Oddi rings after incubation with atropine (1 μM) and guanethidine (4 μM) with threefold and fourfold increases in tissue guanosine 3':5'-cyclic monophosphate and adenosine 3':5'-cyclic monophosphate contents, respectively. These changes were blocked by 30 μM N(G)-nitro-L-arginine methyl ester. Glibenclamide (0.1-10 μM) attenuated the field stimulation-induced relaxation and completely abolished the relaxation produced by 0.1 μM cromakalim. We conclude that nitrergic relaxation of the rabbit sphincter of Oddi comprises a mechanism sensitive to glibenclamide.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalPharmacological Research
Volume36
Issue number2
DOIs
Publication statusPublished - Aug 1997

Fingerprint

Sphincter of Oddi
Glyburide
Rabbits
Cromakalim
Guanethidine
Guanosine
NG-Nitroarginine Methyl Ester
Atropine
Cyclic AMP

Keywords

  • Cyclic nucleotides
  • Field stimulation
  • Glibenclamide
  • Nitric oxide (NO)
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Pharmacology

Cite this

Glibenclamide sensitivity of neural relaxation of the rabbit sphincter of Oddi. / Szilvássy, Z.; Lonovics, J.; Jakab, Ildiko; Nagy, Istvan.

In: Pharmacological Research, Vol. 36, No. 2, 08.1997, p. 129-133.

Research output: Contribution to journalArticle

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