Glancing behind virus load variation in HIV-1 infection

Sebastian Bonhoeffer, Georg A. Funk, Huldrych F. Günthard, Marek Fischer, Viktor Müller

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Although the steady-state virus load during HIV-1 infection is remarkably stable within a patient, it displays variation over several orders of magnitude between patients. Despite intensive research, the host and virus factors that are responsible for the observed variation remain poorly understood. Comparison of model predictions with clinical data suggests that most of the variation in steady-state virus load between patients reflects variation of the net rate at which activated CD4 cells are produced.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalTrends in Microbiology
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2003

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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