GFP transgenic animals in biomedical research: A review of potential disadvantages

N. Lipták, Z. Bosze, L. Hiripi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals' health. Glomerulosclerosis was observed in transgenic mice and rabbits with ubiquitous reporter protein expression. Heart-specific GFP expression evoked dilated cardiomyopathy and altered cardiac function in transgenic mouse and zebrafish lines, respectively. Moreover, growth retardation and increased axon swelling were observed in GFP and yellow fluorescent protein (YFP) transgenic mice, respectively. This review will focus on the potential drawbacks of the applications of GFP transgenic animals in biomedical research.

Original languageEnglish
Pages (from-to)525-530
Number of pages6
JournalPhysiological Research
Volume68
Issue number4
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Dilated cardiomyopathy
  • GFP
  • Glomerulosclerosis
  • Transgenic animals

ASJC Scopus subject areas

  • Physiology

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