Gestagen treatment enhances the tocolytic effect of salmeterol in hormone-induced preterm labor in the rat in vivo

Márta Gálik, Róbert Gáspár, Zoltán Kolarovszki-Sipiczki, George Falkay

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine whether gestagen treatment enhances the effects of β2-mimetics in hormone-induced preterm delivery in pregnant rats in vivo. Study Design: Preterm birth was induced with a combination of mifepristone and prostaglandin E2 on day 19 of pregnancy. The animals were treated with salmeterol or gestagens (progesterone or 17α-hydroxyprogesterone) or their combination. The treatments were launched on different days (15-18) of pregnancy. The efficacy of treatment was determined in terms of the delivery time counted from the mifepristone injection. Results: Salmeterol treatment delayed premature labor by 2.4 hours, whereas the delay because of the gestagen-salmeterol combinations was more than 5 hours. Progesterone had no effect on the delivery time. Conclusion: Parallel treatment with salmeterol and gestagens can be more than twice as effective as salmeterol therapy alone. These results open up a possibility for human trials of combined β2-agonist-gestagen therapy in threatening preterm delivery.

Original languageEnglish
Pages (from-to)319.e1-319.e5
JournalAmerican journal of obstetrics and gynecology
Volume198
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • beta-mimetics
  • gestagens
  • preterm birth
  • rat
  • tocolysis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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