Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia

Hui Li, Namita Mukherjee, Usha Soundararajan, Zsanett Tárnok, C. Barta, Shagufta Khaliq, Aisha Mohyuddin, Sylvester L B Kajuna, S. Qasim Mehdi, Judith R. Kidd, Kenneth K. Kidd

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia.

Original languageEnglish
Pages (from-to)842-846
Number of pages5
JournalAmerican Journal of Human Genetics
Volume81
Issue number4
DOIs
Publication statusPublished - 2007

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Western Asia
Far East
Alleles
Gene Frequency
Population
Southeastern Asia
Alcoholism

ASJC Scopus subject areas

  • Genetics

Cite this

Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. / Li, Hui; Mukherjee, Namita; Soundararajan, Usha; Tárnok, Zsanett; Barta, C.; Khaliq, Shagufta; Mohyuddin, Aisha; Kajuna, Sylvester L B; Mehdi, S. Qasim; Kidd, Judith R.; Kidd, Kenneth K.

In: American Journal of Human Genetics, Vol. 81, No. 4, 2007, p. 842-846.

Research output: Contribution to journalArticle

Li, H, Mukherjee, N, Soundararajan, U, Tárnok, Z, Barta, C, Khaliq, S, Mohyuddin, A, Kajuna, SLB, Mehdi, SQ, Kidd, JR & Kidd, KK 2007, 'Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia', American Journal of Human Genetics, vol. 81, no. 4, pp. 842-846. https://doi.org/10.1086/521201
Li, Hui ; Mukherjee, Namita ; Soundararajan, Usha ; Tárnok, Zsanett ; Barta, C. ; Khaliq, Shagufta ; Mohyuddin, Aisha ; Kajuna, Sylvester L B ; Mehdi, S. Qasim ; Kidd, Judith R. ; Kidd, Kenneth K. / Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. In: American Journal of Human Genetics. 2007 ; Vol. 81, No. 4. pp. 842-846.
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AU - Mukherjee, Namita

AU - Soundararajan, Usha

AU - Tárnok, Zsanett

AU - Barta, C.

AU - Khaliq, Shagufta

AU - Mohyuddin, Aisha

AU - Kajuna, Sylvester L B

AU - Mehdi, S. Qasim

AU - Kidd, Judith R.

AU - Kidd, Kenneth K.

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