Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype

Silvia Selinski, Meinolf Blaszkewicz, Marie Louise Lehmann, Daniel Ovsiannikov, Oliver Moormann, Christoph Guballa, Alexander Kress, Michael C. Tru, Holger Gerullis, Thomas Otto, Dimitri Barski, Günter Niegisch, Peter Albers, Sebastian Frees, Walburgis Brenner, Joachim W. Thüroff, Miriam Angeli-Greaves, Thilo Seidel, Gerhard Roth, Holger Dietrich & 22 others Rainer Ebbinghaus, Hans M. Prager, Hermann M. Bolt, Michael Falkenstein, Anna Zimmermann, Torsten Klein, Thomas Reckwitz, Hermann C. Roemer, Dietrich Löhlein, Wobbeke Weistenhöfer, Wolfgang Schöps, Syed Adibul Hassan Rizvi, Muhammad Aslam, Gergely Bánfi, I. Romics, Michael Steffens, Arif B. Ekici, Andreas Winterpacht, Katja Ickstadt, Holger Schwender, Jan G. Hengstler, Klaus Golka

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing of antituberculosis drugs and bladder cancer epidemiology. In this study we compared a recently published tagging single nucleotide polymorphism (SNP) (rs1495741) to the conventional 7-SNP genotype (G191A, C282T, T341C, C481T, G590A, A803G and G857A haplotype pairs) and systematically analysed if novel SNP combinations outperform the latter. For this purpose, we studied 3177 individuals by PCR and phenotyped 344 individuals by the caffeine test. Although the tagSNP and the 7-SNP genotype showed a high degree of correlation (R=0.933, P

Original languageEnglish
Pages (from-to)673-678
Number of pages6
JournalPharmacogenetics and Genomics
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Acetyltransferases
Single Nucleotide Polymorphism
Genotype
Caffeine
Urinary Bladder Neoplasms
Haplotypes
Epidemiology
Polymerase Chain Reaction
Pharmaceutical Preparations

Keywords

  • rs1041983
  • rs1208
  • rs1799929
  • rs1799930
  • rs1799931
  • rs1801279
  • rs1801280

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

Cite this

Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. / Selinski, Silvia; Blaszkewicz, Meinolf; Lehmann, Marie Louise; Ovsiannikov, Daniel; Moormann, Oliver; Guballa, Christoph; Kress, Alexander; Tru, Michael C.; Gerullis, Holger; Otto, Thomas; Barski, Dimitri; Niegisch, Günter; Albers, Peter; Frees, Sebastian; Brenner, Walburgis; Thüroff, Joachim W.; Angeli-Greaves, Miriam; Seidel, Thilo; Roth, Gerhard; Dietrich, Holger; Ebbinghaus, Rainer; Prager, Hans M.; Bolt, Hermann M.; Falkenstein, Michael; Zimmermann, Anna; Klein, Torsten; Reckwitz, Thomas; Roemer, Hermann C.; Löhlein, Dietrich; Weistenhöfer, Wobbeke; Schöps, Wolfgang; Hassan Rizvi, Syed Adibul; Aslam, Muhammad; Bánfi, Gergely; Romics, I.; Steffens, Michael; Ekici, Arif B.; Winterpacht, Andreas; Ickstadt, Katja; Schwender, Holger; Hengstler, Jan G.; Golka, Klaus.

In: Pharmacogenetics and Genomics, Vol. 21, No. 10, 10.2011, p. 673-678.

Research output: Contribution to journalArticle

Selinski, S, Blaszkewicz, M, Lehmann, ML, Ovsiannikov, D, Moormann, O, Guballa, C, Kress, A, Tru, MC, Gerullis, H, Otto, T, Barski, D, Niegisch, G, Albers, P, Frees, S, Brenner, W, Thüroff, JW, Angeli-Greaves, M, Seidel, T, Roth, G, Dietrich, H, Ebbinghaus, R, Prager, HM, Bolt, HM, Falkenstein, M, Zimmermann, A, Klein, T, Reckwitz, T, Roemer, HC, Löhlein, D, Weistenhöfer, W, Schöps, W, Hassan Rizvi, SA, Aslam, M, Bánfi, G, Romics, I, Steffens, M, Ekici, AB, Winterpacht, A, Ickstadt, K, Schwender, H, Hengstler, JG & Golka, K 2011, 'Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype', Pharmacogenetics and Genomics, vol. 21, no. 10, pp. 673-678. https://doi.org/10.1097/FPC.0b013e3283493a23
Selinski, Silvia ; Blaszkewicz, Meinolf ; Lehmann, Marie Louise ; Ovsiannikov, Daniel ; Moormann, Oliver ; Guballa, Christoph ; Kress, Alexander ; Tru, Michael C. ; Gerullis, Holger ; Otto, Thomas ; Barski, Dimitri ; Niegisch, Günter ; Albers, Peter ; Frees, Sebastian ; Brenner, Walburgis ; Thüroff, Joachim W. ; Angeli-Greaves, Miriam ; Seidel, Thilo ; Roth, Gerhard ; Dietrich, Holger ; Ebbinghaus, Rainer ; Prager, Hans M. ; Bolt, Hermann M. ; Falkenstein, Michael ; Zimmermann, Anna ; Klein, Torsten ; Reckwitz, Thomas ; Roemer, Hermann C. ; Löhlein, Dietrich ; Weistenhöfer, Wobbeke ; Schöps, Wolfgang ; Hassan Rizvi, Syed Adibul ; Aslam, Muhammad ; Bánfi, Gergely ; Romics, I. ; Steffens, Michael ; Ekici, Arif B. ; Winterpacht, Andreas ; Ickstadt, Katja ; Schwender, Holger ; Hengstler, Jan G. ; Golka, Klaus. / Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. In: Pharmacogenetics and Genomics. 2011 ; Vol. 21, No. 10. pp. 673-678.
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AU - Lehmann, Marie Louise

AU - Ovsiannikov, Daniel

AU - Moormann, Oliver

AU - Guballa, Christoph

AU - Kress, Alexander

AU - Tru, Michael C.

AU - Gerullis, Holger

AU - Otto, Thomas

AU - Barski, Dimitri

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AU - Frees, Sebastian

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AU - Hassan Rizvi, Syed Adibul

AU - Aslam, Muhammad

AU - Bánfi, Gergely

AU - Romics, I.

AU - Steffens, Michael

AU - Ekici, Arif B.

AU - Winterpacht, Andreas

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