Genotoxic effectivity - comparison of 36 nitrated furan and arenofuran derivatives on a quantitative scale. Statistical comparison of T7 and other short-term tests

G. Rontó, P. Gróf, J. P. Buisson, J. Einhorn, P. Demerseman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Thirty-six nitrated furan and arenofuran derivatives were measured and quantitatively characterized by the T7 inactivation test. A wide range of substances previously studied allowed us to compare the collected quantitative data with those obtained by other workers using different short-term tests. Based on comparative statistical evaluation of these data a borderline was determined for the genotoxic effect: compounds having in our short-term test mutagenicity index (MI) values smaller than 8.0 are positive while the higher values represent negative genotoxicity. Classification of 36 nitrofuran/nitroarenofuran derivatives is given both on the basis of the quantitative genotoxicity scale and in terms of ± on the qualitative scale. All but one compound were found to be genotoxic and the genotoxic activities of these compounds were compared with the results of other carcinogenicity or mutagenicity tests.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalMutagenesis
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 1992

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Mutagenicity Tests
Carcinogenicity Tests
Nitrofurans
Derivatives
Derivative
furan
Evaluation
Range of data

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Genotoxic effectivity - comparison of 36 nitrated furan and arenofuran derivatives on a quantitative scale. Statistical comparison of T7 and other short-term tests. / Rontó, G.; Gróf, P.; Buisson, J. P.; Einhorn, J.; Demerseman, P.

In: Mutagenesis, Vol. 7, No. 4, 07.1992, p. 243-249.

Research output: Contribution to journalArticle

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