Genomics and Functional Differences of Dendritic Cell Subsets

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dendritic cells (DC) represent a multifunctional population of cells with the capacity to prime and orchestrate antigen-specific immune responses. Human DC are classified into myeloid and plasmacytoid DC with distinct functional activities. Both subsets can be found as resting cells, acting as sensors of environmental changes. Uptake of exogenous material in combination with danger signals induces activation, migration and differentation of DC that transform them into potent antigen-presenting and secretory cells. DC at both activation states interact with other cells via direct cell-to-cell contacts and by released cytokines and chemokines. Depending on the combination of exogenous and endogenous stimuli, both DC subsets can initiate inflammatory or regulatory immune responses. The way in which the various DC subtypes become activated and collaborate with other cells determines the outcome of immune responses against pathogens or malignant cells. The enormous functional flexibility of DC offers new possibilities to manipulate antigen-specific immune responses.

Original languageEnglish
Title of host publicationImmunogenomics and Human Disease
PublisherJohn Wiley & Sons, Ltd
Pages209-247
Number of pages39
ISBN (Print)9780470015308
DOIs
Publication statusPublished - May 16 2006

Keywords

  • Antibody-mediated cellular cytotoxicity
  • Antigen-specific immune responses
  • Carbohydrate recognition domains (CRD)
  • Cell surface receptors
  • Dendritic cells (DC)
  • Proteasome-degraded peptides
  • Scavanger receptors (SR)
  • Tissue localization
  • Tumour-specific antibodies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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