Genomic Investigation of Asthma in Human and Animal Models

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Asthma is a pulmonary disease characterized by increased bronchial responsiveness to a variety of stimuli. It is the most common chronic disease of childhood and the most frequent reason for paediatric hospital admission, and its incidence is on the rise. Several studies have suggested that asthma is a multifactorial disease influenced by genetic and environmental factors. In this review I will systematically summarize collective evidence from linkage and association studies that have consistently reported suggestive linkage or association of asthma or its associated phenotypes to polymorphic markers and single nucleotide polymorphisms in selected chromosomes. Next, I will show some results from animal models of asthma investigating the pathomechanism and the genomic background of the disease.

Original languageEnglish
Title of host publicationImmunogenomics and Human Disease
PublisherJohn Wiley & Sons, Ltd
Pages419-441
Number of pages23
ISBN (Print)9780470015308
DOIs
Publication statusPublished - May 16 2006

Fingerprint

Animals
Asthma
Animal Models
Pulmonary diseases
Pediatrics
Chromosomes
Polymorphism
Inborn Genetic Diseases
Pediatric Hospitals
Nucleotides
Lung Diseases
Single Nucleotide Polymorphism
Chronic Disease
Phenotype
Incidence

Keywords

  • Airflow obstruction
  • Allergic asthma
  • Candidate gene approach
  • Chromosomal localization
  • Eosinophilic inflammation
  • Genetic mapping
  • Genome-wide screen approach
  • Hygiene hypothesis
  • Positional cloning

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Szalai, C. (2006). Genomic Investigation of Asthma in Human and Animal Models. In Immunogenomics and Human Disease (pp. 419-441). John Wiley & Sons, Ltd. https://doi.org/10.1002/0470034092.ch19

Genomic Investigation of Asthma in Human and Animal Models. / Szalai, C.

Immunogenomics and Human Disease. John Wiley & Sons, Ltd, 2006. p. 419-441.

Research output: Chapter in Book/Report/Conference proceedingChapter

Szalai, C 2006, Genomic Investigation of Asthma in Human and Animal Models. in Immunogenomics and Human Disease. John Wiley & Sons, Ltd, pp. 419-441. https://doi.org/10.1002/0470034092.ch19
Szalai C. Genomic Investigation of Asthma in Human and Animal Models. In Immunogenomics and Human Disease. John Wiley & Sons, Ltd. 2006. p. 419-441 https://doi.org/10.1002/0470034092.ch19
Szalai, C. / Genomic Investigation of Asthma in Human and Animal Models. Immunogenomics and Human Disease. John Wiley & Sons, Ltd, 2006. pp. 419-441
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