Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma

Koichi Fukino, Lei Shen, A. Patócs, George L. Mutter, Charis Eng

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Context: That genomic alterations occur in both the epithelium and stroma of sporadic breast cancers has been documented by several groups. However, whether these microenvironmental alterations relate to clinicopathological features is unknown. Objective: To analyze the relationship between stromal genomic alterations and presenting clinicopathological features in sporadic breast cancer. Design, Setting, and Participants: A retrospective cross-sectional analysis of DNA from the epithelium and stroma of 220 primary sporadic invasive breast carcinomas for global genomic alterations manifested by loss of heterozygosity/allelic imbalance with 386 microsatellite markers. Data were collected from October 2003 through June 2006 from samples at Brigham and Women's Hospital, Boston, Mass. Main Outcome Measures: Association of the loss of heterozygosity/allelic imbalance, in both the stroma and epithelium, with presenting clinicopathological features, such as tumor grade, expression status of estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2, clinical stage, and regional lymph node metastasis status. Associations were assessed in regression models and tested with Fisher exact test. Bonferroni correction was applied to P values, with significance set at P

Original languageEnglish
Pages (from-to)2103-2111
Number of pages9
JournalJournal of the American Medical Association
Volume297
Issue number19
DOIs
Publication statusPublished - May 16 2007

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Genomic Instability
Allelic Imbalance
Epithelium
Loss of Heterozygosity
Breast Neoplasms
Neoplasms
Progesterone Receptors
Estrogen Receptors
Microsatellite Repeats
Cross-Sectional Studies
Lymph Nodes
Outcome Assessment (Health Care)
Neoplasm Metastasis
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma. / Fukino, Koichi; Shen, Lei; Patócs, A.; Mutter, George L.; Eng, Charis.

In: Journal of the American Medical Association, Vol. 297, No. 19, 16.05.2007, p. 2103-2111.

Research output: Contribution to journalArticle

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