Abstract
Context: That genomic alterations occur in both the epithelium and stroma of sporadic breast cancers has been documented by several groups. However, whether these microenvironmental alterations relate to clinicopathological features is unknown. Objective: To analyze the relationship between stromal genomic alterations and presenting clinicopathological features in sporadic breast cancer. Design, Setting, and Participants: A retrospective cross-sectional analysis of DNA from the epithelium and stroma of 220 primary sporadic invasive breast carcinomas for global genomic alterations manifested by loss of heterozygosity/allelic imbalance with 386 microsatellite markers. Data were collected from October 2003 through June 2006 from samples at Brigham and Women's Hospital, Boston, Mass. Main Outcome Measures: Association of the loss of heterozygosity/allelic imbalance, in both the stroma and epithelium, with presenting clinicopathological features, such as tumor grade, expression status of estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2, clinical stage, and regional lymph node metastasis status. Associations were assessed in regression models and tested with Fisher exact test. Bonferroni correction was applied to P values, with significance set at P
| Original language | English |
|---|---|
| Pages (from-to) | 2103-2111 |
| Number of pages | 9 |
| Journal | Journal of the American Medical Association |
| Volume | 297 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - May 16 2007 |
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Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma. / Fukino, Koichi; Shen, Lei; Patócs, A.; Mutter, George L.; Eng, Charis.
In: Journal of the American Medical Association, Vol. 297, No. 19, 16.05.2007, p. 2103-2111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma
AU - Fukino, Koichi
AU - Shen, Lei
AU - Patócs, A.
AU - Mutter, George L.
AU - Eng, Charis
PY - 2007/5/16
Y1 - 2007/5/16
N2 - Context: That genomic alterations occur in both the epithelium and stroma of sporadic breast cancers has been documented by several groups. However, whether these microenvironmental alterations relate to clinicopathological features is unknown. Objective: To analyze the relationship between stromal genomic alterations and presenting clinicopathological features in sporadic breast cancer. Design, Setting, and Participants: A retrospective cross-sectional analysis of DNA from the epithelium and stroma of 220 primary sporadic invasive breast carcinomas for global genomic alterations manifested by loss of heterozygosity/allelic imbalance with 386 microsatellite markers. Data were collected from October 2003 through June 2006 from samples at Brigham and Women's Hospital, Boston, Mass. Main Outcome Measures: Association of the loss of heterozygosity/allelic imbalance, in both the stroma and epithelium, with presenting clinicopathological features, such as tumor grade, expression status of estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2, clinical stage, and regional lymph node metastasis status. Associations were assessed in regression models and tested with Fisher exact test. Bonferroni correction was applied to P values, with significance set at P
AB - Context: That genomic alterations occur in both the epithelium and stroma of sporadic breast cancers has been documented by several groups. However, whether these microenvironmental alterations relate to clinicopathological features is unknown. Objective: To analyze the relationship between stromal genomic alterations and presenting clinicopathological features in sporadic breast cancer. Design, Setting, and Participants: A retrospective cross-sectional analysis of DNA from the epithelium and stroma of 220 primary sporadic invasive breast carcinomas for global genomic alterations manifested by loss of heterozygosity/allelic imbalance with 386 microsatellite markers. Data were collected from October 2003 through June 2006 from samples at Brigham and Women's Hospital, Boston, Mass. Main Outcome Measures: Association of the loss of heterozygosity/allelic imbalance, in both the stroma and epithelium, with presenting clinicopathological features, such as tumor grade, expression status of estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2, clinical stage, and regional lymph node metastasis status. Associations were assessed in regression models and tested with Fisher exact test. Bonferroni correction was applied to P values, with significance set at P
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U2 - 10.1001/jama.297.19.2103
DO - 10.1001/jama.297.19.2103
M3 - Article
VL - 297
SP - 2103
EP - 2111
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 19
ER -