Genome-wide association study of prostate cancer-specific survival

Robert Szulkin, Robert Karlsson, Thomas Whitington, Markus Aly, Henrik Gronberg, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Melissa C. Southey, Liesel M. Fitzgerald, Brian E. Henderson, Fredrick R. Schumacher, Christopher A. Haiman, C. Sipeky, Teuvol J. Tammela, Børge G. NordestgaardTimothy J. Key, Ruth C. Travis, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Paul D P Pharoah, Nora Pashayan, Kay Tee Khaw, Janet L. Stanford, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S. Kibel, Cezary Cybulski, Jan Lubinski, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Volker Herrmann, Bernd Holleczek, Jong Y. Park, Thomas A. Sellers, Hui Yi Lim, Chavdar Slavov, Radka P. Kaneva, Vanio I. Mitev, Amanda Spurdle, Manuel R. Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, Jyotsna Batra, Judith A. Clements, Demetrius Albanes, Gerald L. Andriole, Sonja I. Berndt, Stephen Chanock, Susan M. Gapstur, Edward L. Giovannucci, David J. Hunter, Peter Kraft, Loic Le Marchand, Jing Ma, Alison M. Mondul, Kathryn L. Penney, Meir J. Stampfer, Victoria L. Stevens, Stephanie J. Weinstein, Antonia Trichopoulou, Bas H. Bueno-De-mesquita, Anne Tjønneland, David G. Cox, Lovise Maehle, Johanna Schleutker, Sara Lindstrom, Fredrik Wiklund

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Original languageEnglish
Pages (from-to)1796-1800
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

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Genome-Wide Association Study
Prostatic Neoplasms
Survival
Survival Analysis
Cause of Death
Genome

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R. A., ... Wiklund, F. (2015). Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology Biomarkers and Prevention, 24(11), 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543

Genome-wide association study of prostate cancer-specific survival. / Szulkin, Robert; Karlsson, Robert; Whitington, Thomas; Aly, Markus; Gronberg, Henrik; Eeles, Rosalind A.; Easton, Douglas F.; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Benlloch, Sara; Muir, Kenneth; Giles, Graham G.; Southey, Melissa C.; Fitzgerald, Liesel M.; Henderson, Brian E.; Schumacher, Fredrick R.; Haiman, Christopher A.; Sipeky, C.; Tammela, Teuvol J.; Nordestgaard, Børge G.; Key, Timothy J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul D P; Pashayan, Nora; Khaw, Kay Tee; Stanford, Janet L.; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Lubinski, Jan; Kluzniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Herrmann, Volker; Holleczek, Bernd; Park, Jong Y.; Sellers, Thomas A.; Lim, Hui Yi; Slavov, Chavdar; Kaneva, Radka P.; Mitev, Vanio I.; Spurdle, Amanda; Teixeira, Manuel R.; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Batra, Jyotsna; Clements, Judith A.; Albanes, Demetrius; Andriole, Gerald L.; Berndt, Sonja I.; Chanock, Stephen; Gapstur, Susan M.; Giovannucci, Edward L.; Hunter, David J.; Kraft, Peter; Le Marchand, Loic; Ma, Jing; Mondul, Alison M.; Penney, Kathryn L.; Stampfer, Meir J.; Stevens, Victoria L.; Weinstein, Stephanie J.; Trichopoulou, Antonia; Bueno-De-mesquita, Bas H.; Tjønneland, Anne; Cox, David G.; Maehle, Lovise; Schleutker, Johanna; Lindstrom, Sara; Wiklund, Fredrik.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 11, 01.11.2015, p. 1796-1800.

Research output: Contribution to journalArticle

Szulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Henderson, BE, Schumacher, FR, Haiman, CA, Sipeky, C, Tammela, TJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, PDP, Pashayan, N, Khaw, KT, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Lubinski, J, Kluzniak, W, Cannon-Albright, L, Brenner, H, Herrmann, V, Holleczek, B, Park, JY, Sellers, TA, Lim, HY, Slavov, C, Kaneva, RP, Mitev, VI, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Batra, J, Clements, JA, Albanes, D, Andriole, GL, Berndt, SI, Chanock, S, Gapstur, SM, Giovannucci, EL, Hunter, DJ, Kraft, P, Le Marchand, L, Ma, J, Mondul, AM, Penney, KL, Stampfer, MJ, Stevens, VL, Weinstein, SJ, Trichopoulou, A, Bueno-De-mesquita, BH, Tjønneland, A, Cox, DG, Maehle, L, Schleutker, J, Lindstrom, S & Wiklund, F 2015, 'Genome-wide association study of prostate cancer-specific survival', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 11, pp. 1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543
Szulkin R, Karlsson R, Whitington T, Aly M, Gronberg H, Eeles RA et al. Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology Biomarkers and Prevention. 2015 Nov 1;24(11):1796-1800. https://doi.org/10.1158/1055-9965.EPI-15-0543
Szulkin, Robert ; Karlsson, Robert ; Whitington, Thomas ; Aly, Markus ; Gronberg, Henrik ; Eeles, Rosalind A. ; Easton, Douglas F. ; Kote-Jarai, Zsofia ; Al Olama, Ali Amin ; Benlloch, Sara ; Muir, Kenneth ; Giles, Graham G. ; Southey, Melissa C. ; Fitzgerald, Liesel M. ; Henderson, Brian E. ; Schumacher, Fredrick R. ; Haiman, Christopher A. ; Sipeky, C. ; Tammela, Teuvol J. ; Nordestgaard, Børge G. ; Key, Timothy J. ; Travis, Ruth C. ; Neal, David E. ; Donovan, Jenny L. ; Hamdy, Freddie C. ; Pharoah, Paul D P ; Pashayan, Nora ; Khaw, Kay Tee ; Stanford, Janet L. ; Thibodeau, Stephen N. ; McDonnell, Shannon K. ; Schaid, Daniel J. ; Maier, Christiane ; Vogel, Walther ; Luedeke, Manuel ; Herkommer, Kathleen ; Kibel, Adam S. ; Cybulski, Cezary ; Lubinski, Jan ; Kluzniak, Wojciech ; Cannon-Albright, Lisa ; Brenner, Hermann ; Herrmann, Volker ; Holleczek, Bernd ; Park, Jong Y. ; Sellers, Thomas A. ; Lim, Hui Yi ; Slavov, Chavdar ; Kaneva, Radka P. ; Mitev, Vanio I. ; Spurdle, Amanda ; Teixeira, Manuel R. ; Paulo, Paula ; Maia, Sofia ; Pandha, Hardev ; Michael, Agnieszka ; Kierzek, Andrzej ; Batra, Jyotsna ; Clements, Judith A. ; Albanes, Demetrius ; Andriole, Gerald L. ; Berndt, Sonja I. ; Chanock, Stephen ; Gapstur, Susan M. ; Giovannucci, Edward L. ; Hunter, David J. ; Kraft, Peter ; Le Marchand, Loic ; Ma, Jing ; Mondul, Alison M. ; Penney, Kathryn L. ; Stampfer, Meir J. ; Stevens, Victoria L. ; Weinstein, Stephanie J. ; Trichopoulou, Antonia ; Bueno-De-mesquita, Bas H. ; Tjønneland, Anne ; Cox, David G. ; Maehle, Lovise ; Schleutker, Johanna ; Lindstrom, Sara ; Wiklund, Fredrik. / Genome-wide association study of prostate cancer-specific survival. In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 11. pp. 1796-1800.
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AU - Szulkin, Robert

AU - Karlsson, Robert

AU - Whitington, Thomas

AU - Aly, Markus

AU - Gronberg, Henrik

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Benlloch, Sara

AU - Muir, Kenneth

AU - Giles, Graham G.

AU - Southey, Melissa C.

AU - Fitzgerald, Liesel M.

AU - Henderson, Brian E.

AU - Schumacher, Fredrick R.

AU - Haiman, Christopher A.

AU - Sipeky, C.

AU - Tammela, Teuvol J.

AU - Nordestgaard, Børge G.

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Neal, David E.

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Pharoah, Paul D P

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Thibodeau, Stephen N.

AU - McDonnell, Shannon K.

AU - Schaid, Daniel J.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Kluzniak, Wojciech

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Herrmann, Volker

AU - Holleczek, Bernd

AU - Park, Jong Y.

AU - Sellers, Thomas A.

AU - Lim, Hui Yi

AU - Slavov, Chavdar

AU - Kaneva, Radka P.

AU - Mitev, Vanio I.

AU - Spurdle, Amanda

AU - Teixeira, Manuel R.

AU - Paulo, Paula

AU - Maia, Sofia

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - Kierzek, Andrzej

AU - Batra, Jyotsna

AU - Clements, Judith A.

AU - Albanes, Demetrius

AU - Andriole, Gerald L.

AU - Berndt, Sonja I.

AU - Chanock, Stephen

AU - Gapstur, Susan M.

AU - Giovannucci, Edward L.

AU - Hunter, David J.

AU - Kraft, Peter

AU - Le Marchand, Loic

AU - Ma, Jing

AU - Mondul, Alison M.

AU - Penney, Kathryn L.

AU - Stampfer, Meir J.

AU - Stevens, Victoria L.

AU - Weinstein, Stephanie J.

AU - Trichopoulou, Antonia

AU - Bueno-De-mesquita, Bas H.

AU - Tjønneland, Anne

AU - Cox, David G.

AU - Maehle, Lovise

AU - Schleutker, Johanna

AU - Lindstrom, Sara

AU - Wiklund, Fredrik

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AB - Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

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