Genome scan in sibling pairs with juvenile-onset mood disorders: Evidence for linkage to 13q and Xq

Karen Wigg, Yu Feng, Lissette Gomez, Eniko Kiss, Krisztina Kapornai, Zsuzsa Tamás, László Mayer, Ildikó Baji, Gabriella Daróczi, István Benák, Viola Kothencné Osváth, Edit Dombovári, Emília Kaczvinszk, Márta Besnyó, Julia Gádoros, Nicole King, Judit Székely, Maria Kovacs, Ágnes Vetró, James L. KennedyCathy L. Barr

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mood disorders (bipolar and depressive disorders) in children and adolescents are associated with significant morbidity and mortality. Twin and family studies, for the most part, indicate higher familiality and heritability for mood disorders that onset in childhood/adolescence than those that onset in adulthood. To identify the genetic contribution to mood disorders that onset in childhood/adolescence, we performed a genome scan on 146 nuclear families from Hungary containing an affected proband and affected siblings. In total, the pedigrees contained 303 affected children: 146 probands, 137 siblings with a first episode of mood disorder before 14.9 years of age, and 20 siblings with onset of their first episode after 14.9 years of age but before the age of 18. The results of the genome scan using 405 microsatellite markers did not provide evidence for linkage at the recommended genome wide significance level for any novel loci. However, markers on two chromosomes, 13q and Xq, provided evidence for linkage in regions previously identified as linked to bipolar disorder in multiple studies. For the marker on chromosome 13q the peak non-parametric multipoint LOD score was at the marker D13S779 (LOD=1.5, P=0.004). On chromosome Xq, evidence for linkage was observed across a large region spanning two regions previously linked to bipolar disorder; Xq24 to Xq28, with a peak at marker TTTA062 (LOD 2.10, P=0.0009) in Xq28. Results for these regions exceed the recommended P-value for a replication study of P<0.01 and thus provide evidence for these two loci as contributing to mood disorders with juvenile onset.

Original languageEnglish
Pages (from-to)638-646
Number of pages9
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume150
Issue number5
DOIs
Publication statusPublished - Jul 5 2009

    Fingerprint

Keywords

  • Bipolar disorder
  • Child
  • Depression
  • Genetics
  • Genome scan
  • Linkage
  • Mood disorders

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Wigg, K., Feng, Y., Gomez, L., Kiss, E., Kapornai, K., Tamás, Z., Mayer, L., Baji, I., Daróczi, G., Benák, I., Osváth, V. K., Dombovári, E., Kaczvinszk, E., Besnyó, M., Gádoros, J., King, N., Székely, J., Kovacs, M., Vetró, Á., ... Barr, C. L. (2009). Genome scan in sibling pairs with juvenile-onset mood disorders: Evidence for linkage to 13q and Xq. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(5), 638-646. https://doi.org/10.1002/ajmg.b.30883