Genome-scale assessment of molecular pathology in systemic autoimmune diseases using microarray technology: A potential breakthrough diagnostic and individualized therapy-design tool

M. Centola, M. B. Frank, A. I. Bolstad, P. Alex, A. Szanto, M. Zeher, T. O. Hjelmervik, R. Jonsson, B. Nakken, G. Szegedi, P. Szodoray

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Systemic autoimmune rheumatic diseases are of complex aetiology, characterized by an intricate interplay of various factors. A myriad of genes lies behind the heterogeneous manifestations of these diseases, and the overexpression and repression of particular genes form a specific gene-expression profile (genetic fingerprints) that is characteristic to the given disease phenotype. Besides the description of various cell types by using gene-expression profiling, the data should be directly applicable to the design of individual therapeutic protocols for patients suffering from various autoimmune diseases. In this review, we summarize the gene-expression profile, various genetic signatures of different autoimmune diseases and give an overview on the possible interpretations of the data. The application of recent breakthroughs in high-throughput molecular profiling technologies, such as microarray technology has been the basis for a revolution in biomedical research, as well as diagnostics and pharmaceutical development. It is easy to envision a day when personalized medicine, which is the diagnosis and treatment of a given patient with agents and procedures tailored to that patient's genetics, physiology and pathology, will become the standard of care.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalScandinavian Journal of Immunology
Volume64
Issue number3
DOIs
Publication statusPublished - Sep 2006

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Genome-scale assessment of molecular pathology in systemic autoimmune diseases using microarray technology: A potential breakthrough diagnostic and individualized therapy-design tool'. Together they form a unique fingerprint.

  • Cite this