Génétique des néoplasies endocriniennes multiples: Implications cliniques

Translated title of the contribution: Genetics of multiple endocrine neoplasies: Clinical implications

P. Igaz, Rolf C. Gaillard

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The multiple endocrine neoplasia (MEN) syndromes are hereditary monogenic diseases that are transmitted as autosomal dominant traits, and are characterized by the development of tumors and hyperplasias in several endocrine organs. The causative genes of the 2 principal forms of MEN have been recently identified; a protooncogene for MEN2 (the RET gene) and a tumor suppressor gene for MEN1 (the MEN1 gene). Correlations between phenotype and genotype were described in the case of RET mutations that could help in defining the screening methods and the preferable age of prophylactic thyroidectomy. No correlations were established between the mutations of the MEN1 gene and the phenotype of patients suffering from MEN1. We present here a synopsis of the recent results of the genetics of MEN syndromes underlining their clinical implications.

Original languageFrench
Pages (from-to)408-413
Number of pages6
JournalRevue Medicale Suisse
Volume1
Issue number6
Publication statusPublished - Feb 9 2005

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Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia
Genes
Mutation
Inborn Genetic Diseases
Thyroidectomy
Genetic Association Studies
Tumor Suppressor Genes
Hyperplasia
Phenotype
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Génétique des néoplasies endocriniennes multiples : Implications cliniques. / Igaz, P.; Gaillard, Rolf C.

In: Revue Medicale Suisse, Vol. 1, No. 6, 09.02.2005, p. 408-413.

Research output: Contribution to journalArticle

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