Genetic variants of the tumour necrosis factor-alpha promoter gene do not influence the development of necrotizing enterocolitis

A. Treszl, I. Kocsis, M. Szathmári, T. Tulassay, B. Vásárhelyi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Previous studies indicated that elevated tumour necrosis factor-alpha (TNF-α) levels may play a role in the development of necrotizing enterocolitis (NEC). The A-308 and A-238 variants of the promoter region of the TNF-α gene are reportedly associated with altered TNF-α production. The aim of our study was to determine the impact of these gene polymorphisms on the development and course of NEC in very-low-birthweight (VLBW) infants. Dried blood samples from 46 VLBW neonates with NEC were analysed using the method of restriction fragment length polymorphism. Samples from 90 VLBW neonates without NEC were used as controls. The prevalence of alleles with guanine-adenine transition in the -308 and -238 positions was the same in NEC and control subjects (12% vs 10% and 3% vs 4%, respectively). Conclusion: The investigated genetic variants of the TNF-α gene promoter region have no influence on the risk and course of NEC in VLBW infants.

Original languageEnglish
Pages (from-to)1182-1185
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume90
Issue number10
DOIs
Publication statusPublished - 2001

Fingerprint

Necrotizing Enterocolitis
Tumor Necrosis Factor-alpha
Genes
Genetic Promoter Regions
Newborn Infant
Guanine
Adenine
Restriction Fragment Length Polymorphisms
Alleles

Keywords

  • Genetic polymorphism
  • Necrotizing enterocolitis
  • Tumour necrosis factor-alpha
  • Very low-birthweight infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Genetic variants of the tumour necrosis factor-alpha promoter gene do not influence the development of necrotizing enterocolitis",
abstract = "Previous studies indicated that elevated tumour necrosis factor-alpha (TNF-α) levels may play a role in the development of necrotizing enterocolitis (NEC). The A-308 and A-238 variants of the promoter region of the TNF-α gene are reportedly associated with altered TNF-α production. The aim of our study was to determine the impact of these gene polymorphisms on the development and course of NEC in very-low-birthweight (VLBW) infants. Dried blood samples from 46 VLBW neonates with NEC were analysed using the method of restriction fragment length polymorphism. Samples from 90 VLBW neonates without NEC were used as controls. The prevalence of alleles with guanine-adenine transition in the -308 and -238 positions was the same in NEC and control subjects (12{\%} vs 10{\%} and 3{\%} vs 4{\%}, respectively). Conclusion: The investigated genetic variants of the TNF-α gene promoter region have no influence on the risk and course of NEC in VLBW infants.",
keywords = "Genetic polymorphism, Necrotizing enterocolitis, Tumour necrosis factor-alpha, Very low-birthweight infants",
author = "A. Treszl and I. Kocsis and M. Szathm{\'a}ri and T. Tulassay and B. V{\'a}s{\'a}rhelyi",
year = "2001",
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T1 - Genetic variants of the tumour necrosis factor-alpha promoter gene do not influence the development of necrotizing enterocolitis

AU - Treszl, A.

AU - Kocsis, I.

AU - Szathmári, M.

AU - Tulassay, T.

AU - Vásárhelyi, B.

PY - 2001

Y1 - 2001

N2 - Previous studies indicated that elevated tumour necrosis factor-alpha (TNF-α) levels may play a role in the development of necrotizing enterocolitis (NEC). The A-308 and A-238 variants of the promoter region of the TNF-α gene are reportedly associated with altered TNF-α production. The aim of our study was to determine the impact of these gene polymorphisms on the development and course of NEC in very-low-birthweight (VLBW) infants. Dried blood samples from 46 VLBW neonates with NEC were analysed using the method of restriction fragment length polymorphism. Samples from 90 VLBW neonates without NEC were used as controls. The prevalence of alleles with guanine-adenine transition in the -308 and -238 positions was the same in NEC and control subjects (12% vs 10% and 3% vs 4%, respectively). Conclusion: The investigated genetic variants of the TNF-α gene promoter region have no influence on the risk and course of NEC in VLBW infants.

AB - Previous studies indicated that elevated tumour necrosis factor-alpha (TNF-α) levels may play a role in the development of necrotizing enterocolitis (NEC). The A-308 and A-238 variants of the promoter region of the TNF-α gene are reportedly associated with altered TNF-α production. The aim of our study was to determine the impact of these gene polymorphisms on the development and course of NEC in very-low-birthweight (VLBW) infants. Dried blood samples from 46 VLBW neonates with NEC were analysed using the method of restriction fragment length polymorphism. Samples from 90 VLBW neonates without NEC were used as controls. The prevalence of alleles with guanine-adenine transition in the -308 and -238 positions was the same in NEC and control subjects (12% vs 10% and 3% vs 4%, respectively). Conclusion: The investigated genetic variants of the TNF-α gene promoter region have no influence on the risk and course of NEC in VLBW infants.

KW - Genetic polymorphism

KW - Necrotizing enterocolitis

KW - Tumour necrosis factor-alpha

KW - Very low-birthweight infants

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