Genetic variant-associated endothelial dysfunction behind small-vessel cerebral circulatory disorders: A new pathomechanism behind common cerebral phenotypes

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Abstract

An increasing body of evidence suggests that different genetic factors, such as angiotensin-converting enzyme (ACE) I/D, angiotensin II type-1 receptor (ATIR) A1166C, methylenetetrahydrofolate reductase (MTHFR) C677T and ENOS G894T variants are associated with an endothelial dysfunction (ED). EDs are relatively new phenomena that are presumed to contribute to vasoregulatory malfunctions at the small-vessel level. Ever more clinical observations indicate that the above genetic variants are also associated with cerebral small-vessel disorders. This article reviews the knowledge available on the roles of ED- associated genetic variants in cerebral circulatory disorders, and suggests that EDs can be causative factors for different common cerebral pathologies such as leukoaraiosis or/and small-vessel infarcts. Newly-developed drugs involving phosphodiesterase type-5 inhibitors, which improve the endothelial functions, may comprise a new approach to the treatment and prevention of small-vessel cerebral circulatory disorders.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalMini-Reviews in Medicinal Chemistry
Volume7
Issue number5
DOIs
Publication statusPublished - May 1 2007

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Keywords

  • AT1R A1166C
  • Angiotensin-converting enzyme I/D
  • ENOS G894T
  • Endothelial dysfunction
  • Endothelin-1
  • Genetic variant
  • Leukoaraiosis
  • MTHFR C677T
  • Nitric oxide
  • Phosphodiesterase type-5 inhibitors
  • Small-vessel infarcts

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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