Az oxitocinreceptor genetikai variabilitásának in silico elemzése

Translated title of the contribution: Genetic variability of the oxytocine receptor: An in silico study

Marx Péter, Arany Ádám, Z. Rónai, Antal Péter, M. Sasvári

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There is an ongoing extensive study on the polymorphisms of the oxytocine receptor (OXTR) gene and their relation to certain psychological traits and psychiatric disorders, however the results are contradictory. One of the sources of inconsistency could originate from the fact that the OXTR gene contains more than 270 SNPs (single nucleotide polymorphisms) without clarified molecular effect. Goals: The aim of this study was an in silico analysis of sequence variations between the human and dog OXTR gene. Results: Comparative analysis of the human and the dog OXTR amino acid sequence revealed that the most robust difference between the two proteins is a five amino acid containing fragment which is present in the human but absent in the dog receptor. In silico addition of this sequence to the dog receptor resulted in a dramatic change in the conformation of the intracellular region. Conclusion: In silico comparative analysis of OXTR gene variants among species and individuals might serve as an important cue for predicting the functional effects of genetic variants.

Original languageHungarian
Pages (from-to)139-144
Number of pages6
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Computer Simulation
Dogs
Genes
Single Nucleotide Polymorphism
Cues
Sequence Analysis
Psychiatry
Amino Acid Sequence
Psychology
Amino Acids
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Az oxitocinreceptor genetikai variabilitásának in silico elemzése. / Péter, Marx; Ádám, Arany; Rónai, Z.; Péter, Antal; Sasvári, M.

In: Neuropsychopharmacologia Hungarica, Vol. 13, No. 3, 09.2011, p. 139-144.

Research output: Contribution to journalArticle

Péter, Marx ; Ádám, Arany ; Rónai, Z. ; Péter, Antal ; Sasvári, M. / Az oxitocinreceptor genetikai variabilitásának in silico elemzése. In: Neuropsychopharmacologia Hungarica. 2011 ; Vol. 13, No. 3. pp. 139-144.
@article{25593742b1204f90b76c2a0c04c30e4d,
title = "Az oxitocinreceptor genetikai variabilit{\'a}s{\'a}nak in silico elemz{\'e}se",
abstract = "There is an ongoing extensive study on the polymorphisms of the oxytocine receptor (OXTR) gene and their relation to certain psychological traits and psychiatric disorders, however the results are contradictory. One of the sources of inconsistency could originate from the fact that the OXTR gene contains more than 270 SNPs (single nucleotide polymorphisms) without clarified molecular effect. Goals: The aim of this study was an in silico analysis of sequence variations between the human and dog OXTR gene. Results: Comparative analysis of the human and the dog OXTR amino acid sequence revealed that the most robust difference between the two proteins is a five amino acid containing fragment which is present in the human but absent in the dog receptor. In silico addition of this sequence to the dog receptor resulted in a dramatic change in the conformation of the intracellular region. Conclusion: In silico comparative analysis of OXTR gene variants among species and individuals might serve as an important cue for predicting the functional effects of genetic variants.",
keywords = "Dog, Human, Oxytocine, Polymorphism, Receptor",
author = "Marx P{\'e}ter and Arany {\'A}d{\'a}m and Z. R{\'o}nai and Antal P{\'e}ter and M. Sasv{\'a}ri",
year = "2011",
month = "9",
doi = "10.5706/nph201109002",
language = "Hungarian",
volume = "13",
pages = "139--144",
journal = "Neuropsychopharmacologia Hungarica",
issn = "1419-8711",
publisher = "Hungarian Association of Psychopharmacology",
number = "3",

}

TY - JOUR

T1 - Az oxitocinreceptor genetikai variabilitásának in silico elemzése

AU - Péter, Marx

AU - Ádám, Arany

AU - Rónai, Z.

AU - Péter, Antal

AU - Sasvári, M.

PY - 2011/9

Y1 - 2011/9

N2 - There is an ongoing extensive study on the polymorphisms of the oxytocine receptor (OXTR) gene and their relation to certain psychological traits and psychiatric disorders, however the results are contradictory. One of the sources of inconsistency could originate from the fact that the OXTR gene contains more than 270 SNPs (single nucleotide polymorphisms) without clarified molecular effect. Goals: The aim of this study was an in silico analysis of sequence variations between the human and dog OXTR gene. Results: Comparative analysis of the human and the dog OXTR amino acid sequence revealed that the most robust difference between the two proteins is a five amino acid containing fragment which is present in the human but absent in the dog receptor. In silico addition of this sequence to the dog receptor resulted in a dramatic change in the conformation of the intracellular region. Conclusion: In silico comparative analysis of OXTR gene variants among species and individuals might serve as an important cue for predicting the functional effects of genetic variants.

AB - There is an ongoing extensive study on the polymorphisms of the oxytocine receptor (OXTR) gene and their relation to certain psychological traits and psychiatric disorders, however the results are contradictory. One of the sources of inconsistency could originate from the fact that the OXTR gene contains more than 270 SNPs (single nucleotide polymorphisms) without clarified molecular effect. Goals: The aim of this study was an in silico analysis of sequence variations between the human and dog OXTR gene. Results: Comparative analysis of the human and the dog OXTR amino acid sequence revealed that the most robust difference between the two proteins is a five amino acid containing fragment which is present in the human but absent in the dog receptor. In silico addition of this sequence to the dog receptor resulted in a dramatic change in the conformation of the intracellular region. Conclusion: In silico comparative analysis of OXTR gene variants among species and individuals might serve as an important cue for predicting the functional effects of genetic variants.

KW - Dog

KW - Human

KW - Oxytocine

KW - Polymorphism

KW - Receptor

UR - http://www.scopus.com/inward/record.url?scp=84856392535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856392535&partnerID=8YFLogxK

U2 - 10.5706/nph201109002

DO - 10.5706/nph201109002

M3 - Article

VL - 13

SP - 139

EP - 144

JO - Neuropsychopharmacologia Hungarica

JF - Neuropsychopharmacologia Hungarica

SN - 1419-8711

IS - 3

ER -