Genetic variability of gag and env regions of HIV type 1 strains circulating in Slovenia

Mária Mezei, Katalin Balog, Dunja Z. Babič, Gábor Tóth, Gábor Cech, Balázs Vajna, Tamás Tauber, Katja Seme, Janez Tomažič, Ludvik Vidmar, Mario Poljak, János Minárovits

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Abstract

The aim of this study was to investigate the genetic diversity of HIV-1 strains circulating in Slovenia. Proviral DNA isolated from peripheral blood mononuclear cells (PBMCs) of 20 randomly selected HIV-1-infected individuals was classified into subtypes by sequence-based phylogenetic analysis of the env (C2V3) and gag (p24) regions of the viral genome. The phylogenetic tree based on env C2V3 sequences showed that 15 of the 20 samples were subtype B, two A1, one F1, one CRF01_AE, and one CRF02_AG. The phylogenetic analysis of the gag gene yielded identical results expect for one sample that had a discordant subtype; it was identified as subtype A1 in the env and AE in the gag region. Our study confirmed that although subtype B predominates, other subtypes and circulating recombinant forms (CRFs) are also present in Slovenia. The high intrasubtype genetic diversity of subtype B sequences suggests a multiple introduction of subtype B strains into Slovenia.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

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ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Mezei, M., Balog, K., Babič, D. Z., Tóth, G., Cech, G., Vajna, B., Tauber, T., Seme, K., Tomažič, J., Vidmar, L., Poljak, M., & Minárovits, J. (2006). Genetic variability of gag and env regions of HIV type 1 strains circulating in Slovenia. AIDS Research and Human Retroviruses, 22(1), 109-113. https://doi.org/10.1089/aid.2006.22.109