Genetic polymorphisms of vascular endothelial growth factor and angiopoietin 2 in retinopathy of prematurity

Ilona Bányász, Géza Bokodi, Ádám Vannay, Beáta Szebeni, András Treszl, Barna Vásárhelyi, Tivadar Tulassay, András Szabó

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2) contribute to development of retinopathy of prematurity (ROP). We aimed to test whether polymorphisms of these factors are associated with ROP. VEGF - 2578 and Ang2 - 35 polymorphisms were analyzed with PCR-RFLP method in 200 preterm infants without ROP or with ROP stages 1-5. Our results suggest that there is no association between carrier state of VEGF - 2578 and Ang2 - 35 and risk of ROP in preterm infants. The prevalence of VEGF - 2578 "A" allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3).

Original languageEnglish
Pages (from-to)685-690
Number of pages6
JournalCurrent Eye Research
Volume31
Issue number7-8
DOIs
Publication statusPublished - Aug 1 2006

Keywords

  • Angiopoietin 2
  • Genetic polymorphism
  • Preterm infant
  • Retinopathy of prematurity
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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