Genetic polymorphisms for vascular endothelial growth factor in perinatal complications

Ilona Bányász, Géza Bokodi, B. Vásárhelyi, András Treszl, László Derzbach, András Szabó, T. Tulassay, A. Vannay

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Low birth weight (LBW) infants have increased susceptibility to perinatal complications. An immature and impaired vascular system may possibly participate in these complications. There is evidence that supports the notion that vascular endothelial growth factor (VEGF), which is an essential regulator of embryonic angiogenesis, plays a central role in the pathogenesis of perinatal complications. We aimed to test whether functional genetic polymorphisms of VEGF are associated with the risk of preterm birth or perinatal morbidity. We enrolled 128 LBW infants (≤ 1500 grams). VEGF T-460C, VEGF C-2578A and VEGF G+405C polymorphisms were determined by real-time PCR or PCR-RFLP, respectively. Their genotypes were compared with VEGF genotypes of 200 healthy, term neonates. The prevalence of the VEGF+405 C allele was higher in LBW infants than in healthy, term neonates (OR [95% CI]: 1.29 [1.01-1.65]). Carrier state for the VEGF -2578A allele was an independent risk factor for enterocolitis necrotisans (NEC) (adjusted OR [95% CI]: 2.77 [1.00-7.65]). The carrier state for the VEGF -2578AA genotype was associated with a decreased risk of acute renal failure (ARF) (adjusted OR [95% CI]: 0.2 [0.05-0.78]). These results suggest that VEGF G+405C polymorphism might be associated with a higher risk of preterm birth and that VEGF C-2578A polymorphism may participate in the development of perinatal complications such as NEC and ARF.

Original languageEnglish
Pages (from-to)266-270
Number of pages5
JournalEuropean Cytokine Network
Volume17
Issue number4
Publication statusPublished - 2006

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Genetic Polymorphisms
Polymorphism
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor C
Low Birth Weight Infant
Carrier State
Genotype
Premature Birth
Acute Kidney Injury
Alleles
Newborn Infant
Enterocolitis
Restriction Fragment Length Polymorphisms
Blood Vessels
Real-Time Polymerase Chain Reaction
Morbidity
Polymerase Chain Reaction

Keywords

  • Genetic polymorphism
  • Low birth weight infant
  • Perinatal morbidity
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. / Bányász, Ilona; Bokodi, Géza; Vásárhelyi, B.; Treszl, András; Derzbach, László; Szabó, András; Tulassay, T.; Vannay, A.

In: European Cytokine Network, Vol. 17, No. 4, 2006, p. 266-270.

Research output: Contribution to journalArticle

Bányász, Ilona ; Bokodi, Géza ; Vásárhelyi, B. ; Treszl, András ; Derzbach, László ; Szabó, András ; Tulassay, T. ; Vannay, A. / Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. In: European Cytokine Network. 2006 ; Vol. 17, No. 4. pp. 266-270.
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