Genetikai polimorfizmusok mint a terápiás válasz prediktorai hepatitis C-vírus-fertozésben

Translated title of the contribution: Genetic polymorphisms as the predictors of response to antiviral treatment in chronic hepatitis C virus infection

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The review discusses the genetic polymorphisms involved in the pathogenesis of hepatitis C virus (HCV) infection, that may determine the outcome of disease. In this field earlier both certain major histocompatibility complex (MHC) alleles and some cytokine gene variants have also been studied. Recently, the genome-wide association study (GWAS) and targeted single nucleotide polymorphism (SNP) analysis have revealed that a variant in the promoter region of interleukin-28B (IL-28B) gene is strongly linked to viral clearance and it may be the strongest pretreatment predictor of treatment response in chronic hepatitis C. Last year it was shown that two genetic variants leading to inosine triphosphatase deficiency protect against haemolytic anemia in patients receiving ribavirin during antiviral treatment for chronic HCV infection.

Original languageHungarian
Pages (from-to)876-881
Number of pages6
JournalOrvosi Hetilap
Volume152
Issue number22
DOIs
Publication statusPublished - May 1 2011

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Genetic Polymorphisms
Chronic Hepatitis C
Virus Diseases
Hepacivirus
Antiviral Agents
Ribavirin
Genome-Wide Association Study
Interleukins
Hemolytic Anemia
Major Histocompatibility Complex
Genetic Promoter Regions
Genes
Single Nucleotide Polymorphism
Alleles
Cytokines
Therapeutics
Inosine Triphosphatase Deficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genetikai polimorfizmusok mint a terápiás válasz prediktorai hepatitis C-vírus-fertozésben. / Pár, A.

In: Orvosi Hetilap, Vol. 152, No. 22, 01.05.2011, p. 876-881.

Research output: Contribution to journalArticle

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