Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: A twin study

Marcell Szily, Adam D. Tarnoki, David L. Tarnoki, Daniel T. Kovacs, Bianka Forgo, Jooyeon Lee, Eunae Kim, Joohon Sung, Laszlo Kunos, Martina Meszaros, V. Müller, Andras Bikov

Research output: Contribution to journalArticle

Abstract

Background: Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results: The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.

Original languageEnglish
Article number125
JournalRespiratory Research
Volume20
Issue number1
DOIs
Publication statusPublished - Jun 17 2019

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Twin Studies
Obstructive Sleep Apnea
Apnea
Oxygen
Polysomnography
Germany
Registries
Body Mass Index
Morbidity
Mortality
Population

Keywords

  • Environment
  • Heritability
  • Sleep apnoea
  • Sleepiness

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Szily, M., Tarnoki, A. D., Tarnoki, D. L., Kovacs, D. T., Forgo, B., Lee, J., ... Bikov, A. (2019). Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: A twin study. Respiratory Research, 20(1), [125]. https://doi.org/10.1186/s12931-019-1095-x

Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness : A twin study. / Szily, Marcell; Tarnoki, Adam D.; Tarnoki, David L.; Kovacs, Daniel T.; Forgo, Bianka; Lee, Jooyeon; Kim, Eunae; Sung, Joohon; Kunos, Laszlo; Meszaros, Martina; Müller, V.; Bikov, Andras.

In: Respiratory Research, Vol. 20, No. 1, 125, 17.06.2019.

Research output: Contribution to journalArticle

Szily, M, Tarnoki, AD, Tarnoki, DL, Kovacs, DT, Forgo, B, Lee, J, Kim, E, Sung, J, Kunos, L, Meszaros, M, Müller, V & Bikov, A 2019, 'Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: A twin study', Respiratory Research, vol. 20, no. 1, 125. https://doi.org/10.1186/s12931-019-1095-x
Szily, Marcell ; Tarnoki, Adam D. ; Tarnoki, David L. ; Kovacs, Daniel T. ; Forgo, Bianka ; Lee, Jooyeon ; Kim, Eunae ; Sung, Joohon ; Kunos, Laszlo ; Meszaros, Martina ; Müller, V. ; Bikov, Andras. / Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness : A twin study. In: Respiratory Research. 2019 ; Vol. 20, No. 1.
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abstract = "Background: Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results: The prevalence of OSA was 41{\%} in our study population. The heritability of the AHI, ODI and RDI ranged between 69{\%} and 83{\%}, while the OSA, defined by an AHI ≥5/h, was itself 73{\%} heritable. The unshared environmental component explained the rest of the variance between 17{\%} and 31{\%}. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34{\%} by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.",
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AU - Tarnoki, Adam D.

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AU - Kovacs, Daniel T.

AU - Forgo, Bianka

AU - Lee, Jooyeon

AU - Kim, Eunae

AU - Sung, Joohon

AU - Kunos, Laszlo

AU - Meszaros, Martina

AU - Müller, V.

AU - Bikov, Andras

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N2 - Background: Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results: The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.

AB - Background: Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors. Methods: Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied. Results: The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index. Conclusion: OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening.

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