Genetic heterogeneity in the VP7 of group C rotaviruses

Vito Martella, K. Bányai, Eleonora Lorusso, Nicola Decaro, Anna Bellacicco, Costantina Desario, Marialaura Corrente, Grazia Greco, Paschalina Moschidou, Maria Tempesta, Serenella Arista, Max Ciarlet, Antonio Lavazza, Canio Buonavoglia

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Evidence for a possible zoonotic role of group C rotaviruses (GCRVs) has been recently provided. To gain information on the genetic relationships between human and animal GCRVs, we sequenced the VP7 gene of 10 porcine strains detected during a large surveillance study from different outbreaks of gastroenteritis in piglets. Four GCRV strains were genetically related to the prototype GCRV porcine Cowden strain. A completely new VP7 genotype included 4 strains (344/04-7-like) that shared 92.5% to 97.0% aa identity to each other, but <83% to human GCRVs and <79% to other porcine and bovine GCRVs. A unique 4-aa insertion (SSSV or SSTI), within a variable region at the carboxy-terminus of VP7, represented a distinctive feature for these 4 unique strains. An additional strain, 134/04-18, was clearly different from all human and animal GCRVs (<85% aa identity) and likely accounts for a distinct VP7 genotype. The VP7 of a unique strain, 42/05-21, shared similar ranges of aa sequence identities with porcine and human strains (88.0-90.7% to porcine GCRVs and 85.2-88.2% to human GCRVs). Plotting the VP7 gene of strain 42/05-21 against the VP7 of human and porcine strains revealed discontinuous evolution rates throughout the VP7 molecule, suggesting different mutational pressure or a remote intragenic recombination event. These findings provide the need for future epidemiological surveys and warrant studies to investigate the pathogenic potential of these novel GCRVs in pigs.

Original languageEnglish
Pages (from-to)358-366
Number of pages9
JournalVirology
Volume367
Issue number2
DOIs
Publication statusPublished - Oct 25 2007

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Genetic Heterogeneity
Rotavirus
Swine
Genotype
Zoonoses
Gastroenteritis
Genetic Recombination
Genes
Disease Outbreaks
Pressure

Keywords

  • Enteritis
  • Group C rotavirus
  • Pigs
  • Zoonosis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Martella, V., Bányai, K., Lorusso, E., Decaro, N., Bellacicco, A., Desario, C., ... Buonavoglia, C. (2007). Genetic heterogeneity in the VP7 of group C rotaviruses. Virology, 367(2), 358-366. https://doi.org/10.1016/j.virol.2007.05.039

Genetic heterogeneity in the VP7 of group C rotaviruses. / Martella, Vito; Bányai, K.; Lorusso, Eleonora; Decaro, Nicola; Bellacicco, Anna; Desario, Costantina; Corrente, Marialaura; Greco, Grazia; Moschidou, Paschalina; Tempesta, Maria; Arista, Serenella; Ciarlet, Max; Lavazza, Antonio; Buonavoglia, Canio.

In: Virology, Vol. 367, No. 2, 25.10.2007, p. 358-366.

Research output: Contribution to journalArticle

Martella, V, Bányai, K, Lorusso, E, Decaro, N, Bellacicco, A, Desario, C, Corrente, M, Greco, G, Moschidou, P, Tempesta, M, Arista, S, Ciarlet, M, Lavazza, A & Buonavoglia, C 2007, 'Genetic heterogeneity in the VP7 of group C rotaviruses', Virology, vol. 367, no. 2, pp. 358-366. https://doi.org/10.1016/j.virol.2007.05.039
Martella V, Bányai K, Lorusso E, Decaro N, Bellacicco A, Desario C et al. Genetic heterogeneity in the VP7 of group C rotaviruses. Virology. 2007 Oct 25;367(2):358-366. https://doi.org/10.1016/j.virol.2007.05.039
Martella, Vito ; Bányai, K. ; Lorusso, Eleonora ; Decaro, Nicola ; Bellacicco, Anna ; Desario, Costantina ; Corrente, Marialaura ; Greco, Grazia ; Moschidou, Paschalina ; Tempesta, Maria ; Arista, Serenella ; Ciarlet, Max ; Lavazza, Antonio ; Buonavoglia, Canio. / Genetic heterogeneity in the VP7 of group C rotaviruses. In: Virology. 2007 ; Vol. 367, No. 2. pp. 358-366.
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