We investigated the distribution of HLA and immunoglobulin G heavy chain markers (Gm) in 117 patients with Graves' disease, 62 with ophthalmopathy and 55 without. With Graves' disease per se, there is a closer association with HLA‐DR3 than with B8. The opposite was true for Graves' patients with ophthalmopathy (odds ratio for ophthalmopathy associated with B8 was 12.4 and with DR3 was 7.7, both with P < 00005). HLA‐DR7 interacts with B8 in modifying the risk for eye disease; using the phenotype B8‐ DR7‐ as reference, the odds ratios were 16.7 for B8+ DR7 +, 8.7 for B8 + DR7‐ and 0.26 for B8‐ DR7 +. Thus, DR7 enhanced the risk for ophthalmopathy in the presence of B8+ but had a protective influence in its absence. Although Gm showed no association with eye disease, it modified the risk for ophthalmopathy associated with HLA‐B8; the odds ratios were 20.9 for B8+ Gmfb homozygo‐zity (fb +), 15.3 for B8+ fb‐ and 1.7 for B8‐ fb+ (B8‐ fb‐ =1.00). We conclude that the genetic factors contributing to Graves ‘ophthalmopathy are different from those related to liability for Graves’ hyperthyroidism.
|Number of pages||7|
|Publication status||Published - Nov 1986|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism