Genetic-epidemiologic study of haemophilia A and B in Hungary

L. Istvan, E. Czeizel, M. Kerenyi, A. M. Toth, E. Domhy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

All known surviving haemophiliacs A and B and their relatives were reexamined by laboratory and clinical methods and evaluated by a genetic-epidemiologic approach in 4 north-western counties of Hungary. The prevalence of haemophilia A and B patients born in the fifties was 2.73 and 0.25 per 10, 000 persons, respectively. The reproductive fitness was found to be 0.3 in haemophilia A, and 0.8 in haemophilia B patients. The mutation rates calculated by the indirect method were 6.3 x 10.5 for haemophilia A and 0.2 x 10 ° for haemophilia B.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalHuman Heredity
Volume40
Issue number1
DOIs
Publication statusPublished - 1990

Fingerprint

Hemophilia B
Hungary
Hemophilia A
Epidemiologic Studies
Genetic Fitness
Mutation Rate

Keywords

  • Family planning
  • Haemophilia A
  • Haemophilia B
  • Mutation rate
  • Prevalence

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Genetic-epidemiologic study of haemophilia A and B in Hungary. / Istvan, L.; Czeizel, E.; Kerenyi, M.; Toth, A. M.; Domhy, E.

In: Human Heredity, Vol. 40, No. 1, 1990, p. 29-33.

Research output: Contribution to journalArticle

Istvan, L, Czeizel, E, Kerenyi, M, Toth, AM & Domhy, E 1990, 'Genetic-epidemiologic study of haemophilia A and B in Hungary', Human Heredity, vol. 40, no. 1, pp. 29-33. https://doi.org/10.1159/000153898
Istvan, L. ; Czeizel, E. ; Kerenyi, M. ; Toth, A. M. ; Domhy, E. / Genetic-epidemiologic study of haemophilia A and B in Hungary. In: Human Heredity. 1990 ; Vol. 40, No. 1. pp. 29-33.
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