Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994-2014: Origin and evolution of the virus in the region

Gyula Balka, Katarzyna Podgórska, Manreetpal Singh Brar, Ádám Bálint, Daniel Cadar, Vladimir Celer, Lilla Dénes, Zuzana Dirbakova, Anna Jedryczko, Lázár Márton, Dinko Novosel, Tamaš Petrović, Ivo Sirakov, Dóra Szalay, Ivan Toplak, Frederick Chi Ching Leung, Tomasz Stadejek

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the authors collected and analyzed both recent as well as already submitted sequences comparing them to a large backbone set of available ORF5 sequences representing the full spectrum of PRRSV 1 Subtype 1 diversity to conduct a systematic phylogenetic analysis and reclassification elucidating the diversity of the virus in these countries. Moreover, further analyses of the EUROSTAT data regarding the live pig movement trends revealed their influence of virus diversity and evolution. The results indicate that besides the effect of local, isolated divergent evolution and the use of modified live vaccines, the most important factor influencing a given country's virus diversity is the transboundary movement of live, infected animals.

Original languageEnglish
Article number7811
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Balka, G., Podgórska, K., Brar, M. S., Bálint, Á., Cadar, D., Celer, V., Dénes, L., Dirbakova, Z., Jedryczko, A., Márton, L., Novosel, D., Petrović, T., Sirakov, I., Szalay, D., Toplak, I., Leung, F. C. C., & Stadejek, T. (2018). Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994-2014: Origin and evolution of the virus in the region. Scientific reports, 8(1), [7811]. https://doi.org/10.1038/s41598-018-26036-w