Genetic diversity and zoonotic potential of human rotavirus strains, 2003-2006, Hungary

Krisztián Bányai, Ágnes Bogdán, Gertrud Domonkos, Péter Kisfali, Péter Molnár, András Tóth, Béla Melegh, Vito Martella, Jon R. Gentsch, György Szucs

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65 Citations (Scopus)

Abstract

Rotavirus strain surveillance is being conducted in many countries before and after introduction of newly licensed vaccines to assess the impact of the vaccines on rotavirus strains. Here we describe a strain surveillance study in the Budapest area of Hungary (2003-2006) based on RNA profile analysis, genotyping bymultiplex PCR and nucleotide sequencing. Among 1,983 G-typed rotaviruses we identified G1 (22%), G2 (4.8%), G3 (3.5%), G4 (18.5%), G6 (1.1%), G8 (<0.1%, n = 1), G9 (42%), and G12 (3.4%) specificities. Information on P genotype incidence was determined for a subset of samples (n = 814). In addition to the globally important strains, a variety of uncommon antigen combinations were also found, for example, P[9],G3; P[14],G6; or P[14],G8. Sequence and phylogenetic analysis of the VP7, VP4, VP6, and NSP4 genes of selected strains with uncommon antigen combinations demonstrated high similarity with certain bovine, porcine, feline, equine, and lapine rotaviruses, respectively. Continued surveillance is needed to assess the role of animal rotaviruses in human diseases.

Original languageEnglish
Pages (from-to)362-370
Number of pages9
JournalJournal of Medical Virology
Volume81
Issue number2
DOIs
Publication statusPublished - Feb 1 2009

Keywords

  • Genotype
  • Phylogenetic analysis
  • Surveillance

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Bányai, K., Bogdán, Á., Domonkos, G., Kisfali, P., Molnár, P., Tóth, A., Melegh, B., Martella, V., Gentsch, J. R., & Szucs, G. (2009). Genetic diversity and zoonotic potential of human rotavirus strains, 2003-2006, Hungary. Journal of Medical Virology, 81(2), 362-370. https://doi.org/10.1002/jmv.21375