Genetic counselling and prenatal diagnosis of cystic fibrosis in Debrecen (Hungary)--prenatal diagnosis by microvillar enzyme assay from amniotic fluid.

M. Szabó, F. Teichmann, M. Huszka, A. Münnich, L. Veress, Z. Papp

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Amniotic fluid intestinal alkaline phosphatase, gammaglutamyltransferase and trehalase activity were quantitated to assess their reliability for the prenatal diagnosis of cystic fibrosis. To obtain optimal diagnostic discrimination, the three enzyme values obtained for each sample were combined into a single linear discriminant function that proved to be a more accurate indicator of the outcome of the pregnancy. From the cases studied here, it appears that this method can be expected to give a correct prediction in 92.0% of all high risk pregnancies.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalActa Universitatis Carolinae Medica
Volume36
Issue number1-4
Publication statusPublished - 1990

Fingerprint

Trehalase
High-Risk Pregnancy
gamma-Glutamyltransferase
Hungary
Genetic Counseling
Enzyme Assays
Amniotic Fluid
Pregnancy Outcome
Prenatal Diagnosis
Cystic Fibrosis
Alkaline Phosphatase
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genetic counselling and prenatal diagnosis of cystic fibrosis in Debrecen (Hungary)--prenatal diagnosis by microvillar enzyme assay from amniotic fluid. / Szabó, M.; Teichmann, F.; Huszka, M.; Münnich, A.; Veress, L.; Papp, Z.

In: Acta Universitatis Carolinae Medica, Vol. 36, No. 1-4, 1990, p. 132-134.

Research output: Contribution to journalArticle

@article{cb6c8cd6fd6c4401a01cfcd5a09bca42,
title = "Genetic counselling and prenatal diagnosis of cystic fibrosis in Debrecen (Hungary)--prenatal diagnosis by microvillar enzyme assay from amniotic fluid.",
abstract = "Amniotic fluid intestinal alkaline phosphatase, gammaglutamyltransferase and trehalase activity were quantitated to assess their reliability for the prenatal diagnosis of cystic fibrosis. To obtain optimal diagnostic discrimination, the three enzyme values obtained for each sample were combined into a single linear discriminant function that proved to be a more accurate indicator of the outcome of the pregnancy. From the cases studied here, it appears that this method can be expected to give a correct prediction in 92.0{\%} of all high risk pregnancies.",
author = "M. Szab{\'o} and F. Teichmann and M. Huszka and A. M{\"u}nnich and L. Veress and Z. Papp",
year = "1990",
language = "English",
volume = "36",
pages = "132--134",
journal = "Acta Universitatis Carolinae Medica",
issn = "0001-7116",
publisher = "Vydavatelstvi Karolinum",
number = "1-4",

}

TY - JOUR

T1 - Genetic counselling and prenatal diagnosis of cystic fibrosis in Debrecen (Hungary)--prenatal diagnosis by microvillar enzyme assay from amniotic fluid.

AU - Szabó, M.

AU - Teichmann, F.

AU - Huszka, M.

AU - Münnich, A.

AU - Veress, L.

AU - Papp, Z.

PY - 1990

Y1 - 1990

N2 - Amniotic fluid intestinal alkaline phosphatase, gammaglutamyltransferase and trehalase activity were quantitated to assess their reliability for the prenatal diagnosis of cystic fibrosis. To obtain optimal diagnostic discrimination, the three enzyme values obtained for each sample were combined into a single linear discriminant function that proved to be a more accurate indicator of the outcome of the pregnancy. From the cases studied here, it appears that this method can be expected to give a correct prediction in 92.0% of all high risk pregnancies.

AB - Amniotic fluid intestinal alkaline phosphatase, gammaglutamyltransferase and trehalase activity were quantitated to assess their reliability for the prenatal diagnosis of cystic fibrosis. To obtain optimal diagnostic discrimination, the three enzyme values obtained for each sample were combined into a single linear discriminant function that proved to be a more accurate indicator of the outcome of the pregnancy. From the cases studied here, it appears that this method can be expected to give a correct prediction in 92.0% of all high risk pregnancies.

UR - http://www.scopus.com/inward/record.url?scp=0025673648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025673648&partnerID=8YFLogxK

M3 - Article

C2 - 2130675

AN - SCOPUS:0025673648

VL - 36

SP - 132

EP - 134

JO - Acta Universitatis Carolinae Medica

JF - Acta Universitatis Carolinae Medica

SN - 0001-7116

IS - 1-4

ER -