Genetic control of two different types of antibody responses to oxazolone

I. Andó, J. Fachet

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Abstract

The genetic control of antibody responses induced by contact sensitization with oxazolone and immunization with an oxazolone‐mouse serum albumin conjugate was studied in inbred, H‐2‐congenic and nude mice. Both types of antibody responses are T cell‐dependent and regulated by immune response genes mapping at the I‐B subregion of the H‐2 complex. The relative magnitude of antibody responses induced by the two methods of immunization is governed by a gene or genes mapping at the I‐B subregion of the H‐2 complex. Presentation of antigen by these two methods gives H‐2‐dependent distributions of high and low responsiveness which are exactly opposite. Non‐H‐2 genes affect the overall level of antibody response but not the relative magnitude of the responses.

Original languageEnglish
Pages (from-to)516-519
Number of pages4
JournalEuropean journal of immunology
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 1977

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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