Genetic control of contact sensitivity to oxazolone in inbred, H 2 congenic and intra H 2 recombinant strains of mice

J. Fachet, I. Andó

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Abstract

Delayed-type hypersensitivity (DTH) to 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) was found to be under multigenic control in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. A high response was associated with haplotypes H-2(d,a,k) and low response with haplotype H-2(b). DTH to oxazolone was high or intermediate in different F1 hybrids of high and low responder mice. In F2 and backcross generations a higher response was associated with the 'dd', than with the 'bb' phenotype, while intermediate response was found in the heterozygote 'db' mice. A study of H-2 recombinant strains suggests that a gene controlling the DTH response maps in the I-B subregion of the H-2 complex. The response was significantly modified by gene(s) which are not linked to the H-2 complex and have not been mapped. Since congenitally athymic nude (nu/nu) mice did not respond to oxazolone, this contact sensitivity is believed to be a T cell-dependent immune response.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalEuropean Journal of Immunology
Volume7
Issue number4
Publication statusPublished - 1977

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Oxazolone
Contact Dermatitis
Delayed Hypersensitivity
Haplotypes
Heterozygote
Genes
T-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Immunology

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title = "Genetic control of contact sensitivity to oxazolone in inbred, H 2 congenic and intra H 2 recombinant strains of mice",
abstract = "Delayed-type hypersensitivity (DTH) to 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) was found to be under multigenic control in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. A high response was associated with haplotypes H-2(d,a,k) and low response with haplotype H-2(b). DTH to oxazolone was high or intermediate in different F1 hybrids of high and low responder mice. In F2 and backcross generations a higher response was associated with the 'dd', than with the 'bb' phenotype, while intermediate response was found in the heterozygote 'db' mice. A study of H-2 recombinant strains suggests that a gene controlling the DTH response maps in the I-B subregion of the H-2 complex. The response was significantly modified by gene(s) which are not linked to the H-2 complex and have not been mapped. Since congenitally athymic nude (nu/nu) mice did not respond to oxazolone, this contact sensitivity is believed to be a T cell-dependent immune response.",
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T1 - Genetic control of contact sensitivity to oxazolone in inbred, H 2 congenic and intra H 2 recombinant strains of mice

AU - Fachet, J.

AU - Andó, I.

PY - 1977

Y1 - 1977

N2 - Delayed-type hypersensitivity (DTH) to 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) was found to be under multigenic control in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. A high response was associated with haplotypes H-2(d,a,k) and low response with haplotype H-2(b). DTH to oxazolone was high or intermediate in different F1 hybrids of high and low responder mice. In F2 and backcross generations a higher response was associated with the 'dd', than with the 'bb' phenotype, while intermediate response was found in the heterozygote 'db' mice. A study of H-2 recombinant strains suggests that a gene controlling the DTH response maps in the I-B subregion of the H-2 complex. The response was significantly modified by gene(s) which are not linked to the H-2 complex and have not been mapped. Since congenitally athymic nude (nu/nu) mice did not respond to oxazolone, this contact sensitivity is believed to be a T cell-dependent immune response.

AB - Delayed-type hypersensitivity (DTH) to 2-phenyl-4-ethoxymethylene-5-oxazolone (oxazolone) was found to be under multigenic control in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. A high response was associated with haplotypes H-2(d,a,k) and low response with haplotype H-2(b). DTH to oxazolone was high or intermediate in different F1 hybrids of high and low responder mice. In F2 and backcross generations a higher response was associated with the 'dd', than with the 'bb' phenotype, while intermediate response was found in the heterozygote 'db' mice. A study of H-2 recombinant strains suggests that a gene controlling the DTH response maps in the I-B subregion of the H-2 complex. The response was significantly modified by gene(s) which are not linked to the H-2 complex and have not been mapped. Since congenitally athymic nude (nu/nu) mice did not respond to oxazolone, this contact sensitivity is believed to be a T cell-dependent immune response.

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