Genetic basis of tobacco smoking: Strong association of a specifc major histocompatibility complex haplotype on chromosome 6 with smoking behavior

George Füst, Gudmundur J. Arason, Judith Kramer, Csaba Szalai, Jeno Duba, Yan Yang, Erwin K. Chung, Bi Zhou, Carol A. Blanchong, Marja Liisa Lokki, Sigurdur Bödvarsson, Zoltán Prohászka, István Karádi, Ágnes Vatay, Margit Kovács, László Romics, Gudmundur Thorgeirsson, C. Yung Yu

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The genetic basis for addiction to tobacco smoking - particularly that of the perception of olfactory stimuli that may be important in reinforcing smoking addiction - is largely unknown. A cluster of genes for olfactory receptors is in close proximity to the MHC region on chromosome 6. Polymorphisms of MHC class III genes (RCCX modules, TNFA promoter polymorphisms) were determined in 101 healthy subjects and 232 coronary artery disease (CAD) patients from Hungary with defined tobacco smoking habits. A highly significant association between ever smoking (past + current smokers) and a specific MHC haplotype was observed (odds ratios = 2.14-4.13; P-values = 0.012 to <0.001). This haplotype is characterized by the presence of C4A null alleles and a solitary short C4B gene linked to the TNF2 allele of the promoter for TNFA gene. This haplotype occurred more frequently in the ever smokers than in the never smokers [odds ratio: 4.97 (1.96-12.62); P = 0.001], and such associations were stronger in women (odds ratio = 13.6) than in men (odds ratio = 2.79). An independent study of complement C4 protein polymorphism and smoking habits in Icelandic subjects (n = 351) yielded similar and confirmative results. Considering the documented link between olfactory stimuli and smoking in females, and the presence of a cluster of odorant receptor genes close to the MHC class I region, our findings implicate a potential role of the MHC-linked olfactory receptor genes in the initiation of smoking.

Original languageEnglish
Pages (from-to)1507-1514
Number of pages8
JournalInternational Immunology
Volume16
Issue number10
DOIs
Publication statusPublished - Oct 1 2004

Keywords

  • Ancestral MHC haplotype
  • Complement component C4A deficiency
  • Odorant receptors
  • Tobacco smoking
  • Tumor Necrosis factor α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Genetic basis of tobacco smoking: Strong association of a specifc major histocompatibility complex haplotype on chromosome 6 with smoking behavior'. Together they form a unique fingerprint.

  • Cite this