Genetic basis for necrotizing enterocolitis - Risk factors and their relations to genetic polymorphisms

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Necrotizing enterocolitis (NEC) is a common, life-threatening neonatal gastrointestinal disease; it affects approximately 11% of extremely premature neonates. The etiology of NEC is multifactorial. Risk factors may roughly be grouped into four main categories: prematurity; transient ischemia of the intestine; local/systemic inflammation predisposing the bowel to injury, and therapeutic interventions. Recent studies have shown that carrier state of genetic polymorphisms may be associated with perinatal morbidity, including NEC. In perinatal disorders, the significance of genetic variants of cytokines, the reninangiotensin-aldosterone system, and surfactant proteins have been investigated most widely. Positive findings indicate the implication of genetic polymorphisms of proinflammatory cytokines in premature birth; angiotensin converting enzyme in perinatal adaptation and angiotensin type 1 receptor in the closure of ductus arteriosus; surfactant proteins A and B in respiratory distress syndrome; interleukin (IL)-6 in sepsis, and IL-4-receptor α chain and IL-18 in NEC. This review provides an insight into the genetics of NEC and summarizes genetic data in light of pathologic processes leading to NEC.

Original languageEnglish
Pages (from-to)570-580
Number of pages11
JournalFrontiers in Bioscience
Volume11
Issue number1 P.447-888
DOIs
Publication statusPublished - 2006

Fingerprint

Necrotizing Enterocolitis
Genetic Polymorphisms
Polymorphism
Interleukin-4 Receptors
Pulmonary Surfactant-Associated Protein A
Cytokines
Angiotensin Type 1 Receptor
Interleukin-18
Peptidyl-Dipeptidase A
Aldosterone
Surface-Active Agents
Interleukin-6
Infant, Newborn, Diseases
Ductus Arteriosus
Carrier State
Inborn Genetic Diseases
Proteins
Gastrointestinal Diseases
Premature Birth
Pathologic Processes

Keywords

  • Genetic Polymorphism
  • Necrotizing Enterocolitis
  • Preterm Neonate
  • Review
  • Risk Factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Genetic basis for necrotizing enterocolitis - Risk factors and their relations to genetic polymorphisms. / Treszl, Andras; Tulassay, T.; Vásárhelyi, B.

In: Frontiers in Bioscience, Vol. 11, No. 1 P.447-888, 2006, p. 570-580.

Research output: Contribution to journalArticle

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