A rheumatoid arthritis genetikai hátteréról egy családfa kapcsán.

Translated title of the contribution: Genetic background of rheumatoid arthritis in connection with a family tree

T. Nemes, E. Gyódi, F. Szanyó, K. Rajczy, G. Petrányi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Authors present a rare history of a family with accumulation of autoimmune diseases. From eight siblings four had rheumatoid arthritis, one systemic lupus erythematodes, one primary Sjögren syndrome, and one Reiter disease. Interestingly, neither the parents nor the offsprings were affected. Because of the possible genetic background, the authors performed HLA serologic and DNA investigations in nine members of the family. The results showed, in agreement with data from the literature, the accumulation of HLA-DQ7 (DQB1*0301), DR4, B27 and DR6 (DR13) risk factors. This observation confirms, that the clinical and immunogenetic features are different in familiar and sporadic forms of rheumatoid arthritis. Authors summarize the genetic background of rheumatoid arthritis in connection with this family tree.

Translated title of the contributionGenetic background of rheumatoid arthritis in connection with a family tree
Original languageHungarian
Pages (from-to)2785-2790
Number of pages6
JournalOrvosi hetilap
Volume142
Issue number50
Publication statusPublished - Dec 16 2001

ASJC Scopus subject areas

  • Medicine(all)

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