A koleszterinfelszívódás hatékonysá gának genetikai háttere. A Niemann-Pick C1-like-1 receptor és génvariációinak szerepe a lipidanyagcseré ben

Translated title of the contribution: Genetic background of cholesterol absorption effi cacy. the role of Niemann-Pick C1-like 1 receptor and its genetic variation in lipid metabolism

M. Harangi, I. Balogh, János Harangi, G. Paragh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Niemann-Pick C1-like 1 is a sterol sensing domain-containing transmembrane protein that is highly expressed on the apical surface of absorptive enterocytes. Previous studies proved that this protein facilitates the movement of free cholesterol from the gut lumen into enterocytes. Biochemical studies showed that Niemann-Pick C1-like 1 is the target of ezetimibe, a potent cholesterol absorption inhibitor. Recent studies show that genetic variation in Niemann-Pick C1-like 1 may be responsible for the inter-individual variability observed in the rates of intestinal cholesterol absorption and the response to ezetimibe.

Original languageHungarian
Pages (from-to)1376-1383
Number of pages8
JournalOrvosi Hetilap
Volume151
Issue number34
DOIs
Publication statusPublished - Aug 1 2010

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Enterocytes
Lipid Metabolism
Cholesterol
Anticholesteremic Agents
Intestinal Absorption
Sterols
Proteins
Genetic Background
Ezetimibe

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "A koleszterinfelsz{\'i}v{\'o}d{\'a}s hat{\'e}konys{\'a} g{\'a}nak genetikai h{\'a}ttere. A Niemann-Pick C1-like-1 receptor {\'e}s g{\'e}nvari{\'a}ci{\'o}inak szerepe a lipidanyagcser{\'e} ben",
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