Genetikai és immunológiai tényezo″k a gluténszenzitív enteropathia és az asszociált csontmetabolikus eltérések patogenezisében

Translated title of the contribution: Genetic and immunological processes in the pathomechanism of gluten-sensitive enteropathy and associated metabolic bone disorders

Edit Vereckei, G. Poór, E. Kiss

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Celiac disease or gluten-sensitive enteropathy is the most common disease of jejunum, leading to malabsorption. It is an immune mediated disease induced by gluten at the presence of genetic predisposition. After gluten exposition, immune processes are induced by T-cell mediation causing typical intestinal and extra intestinal manifestations. The diagnosis of celiac disease is still set up on the result of jejunal biopsy and detecting of antibodies against endomysium and tissue transglutaminase. From genetic aspect, association with HLA DQ2/DQ8 is identified in celiac disease. On a strict gluten-free diet, the clinical, histological and serological results improve and remission of accompanying diseases may be achieved. In the etiopathogenesis of celiac disease several genetic and immunological mechanisms have been recognized in recent years. Connected to the accompanying diseases, more reviews have been issued about the bone metabolic changes and less about the inflammatory join disorders. In the present work authors review literature data that reveal common background from both immunological and genetic aspects.

Original languageHungarian
Pages (from-to)372-377
Number of pages6
JournalOrvosi Hetilap
Volume151
Issue number10
DOIs
Publication statusPublished - Mar 1 2010

Fingerprint

Genetic Phenomena
Celiac Disease
Bone and Bones
Glutens
Gluten-Free Diet
Immune System Diseases
Jejunum
Genetic Predisposition to Disease
T-Lymphocytes
Biopsy
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genetikai és immunológiai tényezo″k a gluténszenzitív enteropathia és az asszociált csontmetabolikus eltérések patogenezisében. / Vereckei, Edit; Poór, G.; Kiss, E.

In: Orvosi Hetilap, Vol. 151, No. 10, 01.03.2010, p. 372-377.

Research output: Contribution to journalArticle

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