Genetic and environmental effects on carotid flow velocities: Aninternational twin study

Pierleone Lucatelli, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Maria Fabrizia Giannoni, Marianna Gazzetti, Emanuele Boatta, Chiara Zini, Rodolfo Cotichini, Claudio Baracchini, Giorgio Meneghetti, Lorenza Nisticó, Corrado Fagnani, K. Karlinger, Tamas Horvath, Andrea Agnes Molnar, Zsolt Garami, Emanuela Medda, Maria Antonietta Stazi, V. Bérczi, Fabrizio Fanelli

Research output: Contribution to journalArticle

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Abstract

Introduction: Altered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV. Methods: 193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53±14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis. Results: Age- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63%. Unique environmental factors contributed to 37% of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56% and 63%, and between 37% and 44% adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82%) with modest heritability (18%). Conclusions: Our study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalAtherosclerosis
Volume231
Issue number2
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Twin Studies
Internal Carotid Artery
Blood Flow Velocity
Common Carotid Artery
Hungary
Individuality
Italy
Color

Keywords

  • Atherosclerosis
  • Carotid velocities
  • Heritability
  • Twins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lucatelli, P., Tarnoki, A. D., Tarnoki, D. L., Giannoni, M. F., Gazzetti, M., Boatta, E., ... Fanelli, F. (2013). Genetic and environmental effects on carotid flow velocities: Aninternational twin study. Atherosclerosis, 231(2), 205-210. https://doi.org/10.1016/j.atherosclerosis.2013.08.032

Genetic and environmental effects on carotid flow velocities : Aninternational twin study. / Lucatelli, Pierleone; Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Giannoni, Maria Fabrizia; Gazzetti, Marianna; Boatta, Emanuele; Zini, Chiara; Cotichini, Rodolfo; Baracchini, Claudio; Meneghetti, Giorgio; Nisticó, Lorenza; Fagnani, Corrado; Karlinger, K.; Horvath, Tamas; Molnar, Andrea Agnes; Garami, Zsolt; Medda, Emanuela; Stazi, Maria Antonietta; Bérczi, V.; Fanelli, Fabrizio.

In: Atherosclerosis, Vol. 231, No. 2, 12.2013, p. 205-210.

Research output: Contribution to journalArticle

Lucatelli, P, Tarnoki, AD, Tarnoki, DL, Giannoni, MF, Gazzetti, M, Boatta, E, Zini, C, Cotichini, R, Baracchini, C, Meneghetti, G, Nisticó, L, Fagnani, C, Karlinger, K, Horvath, T, Molnar, AA, Garami, Z, Medda, E, Stazi, MA, Bérczi, V & Fanelli, F 2013, 'Genetic and environmental effects on carotid flow velocities: Aninternational twin study', Atherosclerosis, vol. 231, no. 2, pp. 205-210. https://doi.org/10.1016/j.atherosclerosis.2013.08.032
Lucatelli P, Tarnoki AD, Tarnoki DL, Giannoni MF, Gazzetti M, Boatta E et al. Genetic and environmental effects on carotid flow velocities: Aninternational twin study. Atherosclerosis. 2013 Dec;231(2):205-210. https://doi.org/10.1016/j.atherosclerosis.2013.08.032
Lucatelli, Pierleone ; Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Giannoni, Maria Fabrizia ; Gazzetti, Marianna ; Boatta, Emanuele ; Zini, Chiara ; Cotichini, Rodolfo ; Baracchini, Claudio ; Meneghetti, Giorgio ; Nisticó, Lorenza ; Fagnani, Corrado ; Karlinger, K. ; Horvath, Tamas ; Molnar, Andrea Agnes ; Garami, Zsolt ; Medda, Emanuela ; Stazi, Maria Antonietta ; Bérczi, V. ; Fanelli, Fabrizio. / Genetic and environmental effects on carotid flow velocities : Aninternational twin study. In: Atherosclerosis. 2013 ; Vol. 231, No. 2. pp. 205-210.
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AU - Gazzetti, Marianna

AU - Boatta, Emanuele

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